What Aging & Environment Does to Your Skin (and what to do about it) – with Amitay Eshel

Dr. Mindy Pelz  

On this episode of The resetter podcast, I am bringing you, Amitay Eshel. So we have to talk about skin. I have not done a deep dive into skin, especially for those of us over 40. And Ahmed Ty was the guy to bring to you and you’re going to understand why here in a moment. When it comes to the skin changes that happened to us through the perimenopause and menopausal years, they’re pretty dramatic, right? I mean, I’m just really being transparent. And I feel like I know for myself, that I’m not willing to detoxify my body to stay young. My Hormonal Health is really important to me. And I’m always thinking, what is that product going to do for me 1020 30 years from now. But when it comes to skincare, it’s the Wild Wild West, how do we know what habits we should be doing? Should we be staying out of the sun? Should we be putting sunscreen on? Do we need to be looking at certain foods? What nutrients do we need to be eating to be able to enhance better skin performance? This conversation answers all of that. And automatize did an incredible job at breaking this down so that we understand the lifestyle that goes with great menopausal skin. It’s so fascinating. I mean, there were so many things that he really enlightened to me about what’s the purpose of skin, once we stop having a regular cycle? I never thought about that. He addresses that. We also went into all forms of light. What do I need to know about sunlight? What do I need to know about blue light? And what I need to know about red light is red light healing for my skin, that part of the conversation is going to blow you away. Then we also went into Botox. I needed somebody who had a more holistic view to really help me understand should we Botox? Should we not? What are some of the downsides? Of course, we know the upsides. But what do we need to think about and he did a really good job of navigating that part of the conversation. Because he is dressed if you’re going to do Botox, here’s some lifestyle things you need to think about around Botox. After this conversation was over, we actually had a discussion about when we paralyze the face, how often people can’t read our emotions. That was fascinating. I wish we had recorded that part. But there’s a lot to think about when it comes to Botox. And then we really went into topicals at the end, like what do you need to look for when you’re getting a beauty regime in order? Like how do we step out of the toxic beauty conversation that is happening to so many people? Like how do we go after skincare products that are not endocrine disruptors? And what I love about what Alma Tate and his wife have done with their youngest products, is they’ve brought in a lot of the things that I’m doing for my overall health, like NAD, and stimulated in autophagy through fasting and looking at certain supplements like spermidine. And they now have made these topical. And so I’m so excited for this conversation. I think it’s going to help you make better decisions for you when it comes to what path you decide to go after with skincare. Alma Tate and his wife have created incredible products, incredible products with the youngest in a way that I’ve never seen anybody create before. And I just am so excited to bring him to you. If you’re interested in trying his products, there is a discount off your first order, stay all the way through to the end because I asked him what’s the door into his products if we choose to use that. But as always, I want to give you lifestyle first. And that’s what the majority of this conversation is about. So if you love it, send this out into the world. Leave me a review. Let me know how conversations like this are benefiting you. So I can always customize this podcast to your health needs. So Ahmed Tay and Yungas and a whole discussion on skin. Here you go. Enjoy. Welcome to the resetter podcast. This podcast is all about empowering you to believe in yourself again. If you have a passion for learning, if you’re looking to be in control of your health and take your power back, this is the podcast for you. We’re just gonna jump right in and I just want to say welcome to Amitay. I am so excited to have this conversation with you. Probably because I’m curious about skincare Air after 40. It’s something I have definitely tried to navigate. I’m not really sure I’ve been too successful at it. So thank you for joining me here and answering all my burning questions for me. It’s

Amitay Eshel  

my pleasure. And it’s also very, very, very interesting that you are categorizing it past 40. Because intuitively that’s like, extremely Correct. Like it is a completely different conversation you need to have in your skin once you pass your once you’re flirting with perimenopause, the conversation is completely different. Thank

Dr. Mindy Pelz  

you. Okay, thank you for saying that. And I’m just going to start off with, when we look at what happens hormonally, it’s really the loss I think of and correct me if I’m wrong, I’m faster dial. So Esther dial goes away, and then all of a sudden college and goes away. And and for many of us, we just start looking in the mirror and we’re like, Whoa, what is going on and and it’s it’s a little you know, I can just say as a woman, it’s a little startling, to see yourself age, and then you start wanting to go into the Botox is and the fillers and you’re like scrambling for a solution. So can you talk a little bit about what is happening to our skin after 40? And why do we see changes in the mirror and the reflection that is looking back at us?

Amitay Eshel  

Yes, so first of all, your kind of conversation starting with Esther dial is like a very good conversation, because it’s the easiest one to make, you know, that’s kind of what powers college and production, but actually, where we’re, I would like even to take a step back. And because, you know, for some women, it could be, you know, actually the reduction of of testosterone and growth hormone than that, kind of shift that conversation for us, it could be actually again, a part of like the changing in sleep pattern in the interaction with glucose or with insulin, that would that would create that conversation. But really, what we want to think of is the fact that once we you know, once we are stopping to be a person that is that the body is orienting childbearing, the body basically says to the skin, hey, instead of being that communication organ for virality, and vitality, this is like the the the most the most important aspect of the visual, the visual interaction of the skin becomes it becomes basically more and more a barrier more and more of that barrier between our environment and our body. And it really needs to preserve what most people don’t think about, probably don’t know, but don’t think about is your skin is literally a messenger between the environment and your body. So how it interacts with UV pollutants, you know, different things that are going on in the environment, we’re now talking about coronal flares happening in the world. So that is a part of it. So it actually relays stress back to the brain. And that is very important for our, for our brain to kind of preserve alongside other things, so it kind of says, you know, what, I’m not into showing you that, um, you know, aesthetically or that I want to that, um, you know, child burial. Yes. Yeah, exactly. And that those are part of the, you know, the changes that were that we’re experiencing.

Dr. Mindy Pelz 

Yeah, okay, you bring up such an important point. And it’s really been at the root of what I’ve been teaching about the peri menopausal years is that there’s so much that happens in the female body that’s built towards reproduction. And so the challenge with that is once estradiol goes away, and our body is not meant to be reproducing, we’re not just losing, you know, brain power, we’re not just getting hot flashes, but there’s this whole biochemical change that’s going on. So what I just heard from you, is your skin no longer becomes the organ that attracts people to you, your skin becomes the organ that reflects something to you, which is what is the environment that you are putting yourself in. So what is that though? Am I reading that right? You

Amitay Eshel  

are just, it’s not even, it’s not even such a like a top down type of process where the skin decides that it wants to be something else, basically just abandons or slowly slowly abandons or de prioritizes the communication of again of life, life fullness in the skin, the youthfulness of the skin, it just slowly abandons it, it could be epigenetically. It could be basically not maintaining genes that are connected to collagen production, hyaluronic production, hedonic acid production. Last production, the usage of all of those things it could be, what we know is kind of the hallmarks of aging, the names that we give the different dimensions of aging, the different verticals of aging, and how they basically get abandoned by the skin, a lot less mitochondrial function, for example, or even less mitochondria, per cell, et cetera, et cetera. Really, it goes on. That’s why I like to tell a broader story. Because what I’m saying is, think of priorities in the skin not prioritizing Lux anymore, the skin is priority prioritizing other things,

Dr. Mindy Pelz  

what is it so what else is it prioritizing, it

Amitay Eshel  

actually becomes more of a sort of a barrier between the environment and our body. So basically, the more sun damage we experience, the more we we are exposed to like artificial light, or EMS or pollution, heavy metals, the more the skin gets damaged, but also things start to seep into the body, whether it is damaging the, you know, your your connection between your skin and your brain, which is called the skin, brain axis, whether it is damaging your, again, your skin barrier in allowing different contaminants kind of to pass through, or a different era tends to affect the inflammatory levels of the skin. So the skin really shifts to battle these things. It’s not necessarily by a conscious decision, it’s just by an overwhelming amount of assault that happens with time and gets accumulated. And really, we really can think of that of skin aging as the accumulation of unrepaired damage. So the more unrepaired damage there is the more it needs to address that damage, not necessarily maintain its youthful state.

Dr. Mindy Pelz  

So if let’s use me as an example, I was a competitive tennis player. So I grew up on a tennis court in the 70s, in the 80s, when we weren’t really thinking about, you know, sunblock as much. And I often have asked myself as I moved through my 40s and 50s, if the sun damage from my younger years is what I’m seeing now and reflecting now. So do you take the damage from your younger years into those Peri menopausal years? And they just get more amplified at that moment?

Amitay Eshel  

Yeah, imagine, you know, we get sun damage all the time, right? We get, you know, different kinds of irritations all the time, when we’re younger, our body has more resources to deal with it. And these resources also deplete as we mentioned, this or that, but really, these resources deplete as time goes on. And this is a snowball where the more the less we can deal with something, the more we kind of have to deal with the accumulation of it in to answer your you’d like your question specifically, yes, UV, even though I like to say that when we live in a western world, UV is not the number one word we should we should address. UV creates damage, which is extremely hard for the skin to repair because it literally fuses parts of your DNA together. It literally renders them inoperable. So it’s very difficult for your skin to kind of bounce back off of that. I’m not saying that it’s impossible, not saying that it’s, you know, it’s the end of the world. But it is, again, what we’re looking at is just the accumulation statistics. And kind of as time goes on, you know, you’re facing an uphill battle.

Dr. Mindy Pelz  

Yes. So let’s go with the sun. And then I want to I want, I definitely want to know what the number one thing we should be concerned about is, but if we just go with the sun, here’s the dilemma that I have found myself in as a 54 year old woman, is I’m also trying to bring my vitamin D levels up. So I’m in a little bit of a quandary because I need to bring vitamin D up for hormonal production. I know I get vitamin D from the sun. So I’m supplementing with it and doing less with the sun, but we know light is really important for a lot of things. So is there a safe way for perimenopause and menopausal women to do the sun because the minute I put a sunblock on, now I’m blocking the UV rays that will convert help me make vitamin D?

Amitay Eshel  

Yeah, yeah, you’re right. You’re right. I

Dr. Mindy Pelz  

run from the sun away from me in the sun to be friends. You’re

Amitay Eshel  

running circles and then sometimes you get vitamin D? No, it’s pretty much well, you first of all, you’re right, this the second thing is, let me ask the proverbial you the purse the person who listens to us. What hours are we going outside? And then not only that, but also which body parts are we exposing? Do you know what a farmer’s tan is? Yes,

Dr. Mindy Pelz  

I do know that. When I was a kid, we had an absolute tennis tan so and it was a farmer’s

Amitay Eshel  

tan. Yes, exactly. So basically it means that the areas we expose the skin the most, which is like all the way to our like V neck and our arms, they get tanned, and the rest doesn’t. And this is something to bear in mind, not necessarily I know we said we’re kind of limiting it to UV. But these areas also when you walk around inside your house as well, when you’re exposed to artificial lighting, and pollutants, all of these things, these areas are the most stressed out, they have the most amount of, of inflammatory markers, and the most amount of of oxidative stress as well like free radicals as well. So anyway, they’re not the best areas to expose to the sun, if we want to get vitamin D synthesis. So there are a few things that you can do. But I would highly recommend exposing areas that are not exposed normally. So basically, you’re, your belly button area, your upper thighs, the back areas that are, first of all very large, you can think of them like solar panels, right. And not necessarily areas like our face, our ears, our arms, these areas are any way. Basically, by the time we’re we’re learning this information, and we’re in our late 30s 40s 50s, whoever’s listening now 60s, you have now made them a very poor solar panel, and you, you should prioritize other areas, especially if you don’t live in Florida like I do, especially if you live in a place that is more of the Sun is more scarce, I would say again, we are looking at the angle of the sun to the earth. And that changes the relationship of different UV rays and red and near infrared and the makeup of the sun ray. So we really want to kind of expose our skin to the sun before 10am Or after 4pm. And that would help many other things such as you know, your circadian rhythm, which I’m sure you’ve talked about, probably a lot. But yeah,

Dr. Mindy Pelz  

so Okay, so I could put a hat on, I could go in my backyard. And to think of how I expose the largest part of my skin, which the back of that makes perfect sense. And if I do that, you know, making sure it’s not between 10 and four, that I can still get my vitamin D requirements. And do we have any idea of like, is it 20 minutes? 30 minutes, we know how long I should be out there?

Amitay Eshel  

And again, that’s actually the again, great question that would really depend on when exactly you are exposed to the sun. And so for the most part, I say 30 minutes are great, even up to an hour if you’re kind of at the crack of dawn, you can even do two hours, because the sun is so weak in the beginning. And just to give you an example, you know, many people in the last few years I’ve heard about the trends of like turning your butt to the sun and then oh, yeah, that area. And so in the biohacking community, it’s kind of funny to me where you’re saying, Hey, I don’t want to use any kind of sun protection because I’m worried about my vitamin d3 levels, etc. But I’m also understanding the concept of the thing that is exposed less than the sun creates more vitamin D. So if you’re following the second principle, I just said there is no reason like to, you know, beat a dead horse. There is no reason for you to continuously expect your face, your neck, your arms to be the vitamin D synthesizer, right.

Dr. Mindy Pelz  

Okay. Yeah, and I do believe that supplementation, you know, if it can work for you, I you know, that’s kind of where I’ve settled in as just let me supplement. I spent some time this year in Norway, in Trump’s, which is one of the most northern cities in the world where people live. It’s dark three months a year, and they just don’t know you take vitamin D, like, it’s just part of the process. So I, I sort of listened to that. And I go, Yeah, I think that’s just going to be how I’ll get my vitamin D. But I also know I go out in the sun. I have serotonin receptor sites in my eyes. So I want to make sure that I’m not out there with sunglasses on so that I’m stimulating that, like, we’re learning so much more about the healing effect of light. And then to square that with aging skin has been a real dilemma, and I think a lot of women are are experiencing that

Amitay Eshel  

front 100% But I do have some tips. I do have some that you can do. Okay, so we’ll go from like, very easy to maybe a little bit less comfortable. So very, very easy would be taking esta Xanten which is karate annoyed from shiv, mainly from salmon it’s made. So this is something you can take pills a lot of people apply on the skin as well. It’s actually not as good because we want it kind of from within our body. So that is the carotenoids know how to get your skin to surface really, really well. So we want to do that. And we can actually test there is a machine that tests your carotid levels. And we know that this is an amazing product to use in order to kind of get yourself more resilient to the sun and love that supplementing it on a regular basis with SS Anthon is equal to upping your natural protection from the sun by about SPF five, not five. But that’s pretty good. Yes, another four. Another way which is pretty easy is to use a vitamin C that’s called magnesium ascorbyl phosphate Maquet. And the reason I’m giving you that specific type of magnesium is not necessarily because it’s our sorry that that type of Vitamin C is not necessarily because it’s the only one, it’s just the one that shows better efficacy. Part of the reason is that it’s water soluble, and it’s nonsense Stetic. So ascorbic acid which most people know is Vitamin C is actually horrible to use for your skin, we can definitely get into that later, but it is Gino and cytotoxic. So it’s probably the worst ingredient you can have in your skincare regimen,

Dr. Mindy Pelz  

vitamin C,

Amitay Eshel  

the synthetic version, ascorbic acid is really, really, really, really bad as a squid

Dr. Mindy Pelz  

product. Okay, what about if I do a vitamin C drip?

Amitay Eshel  

Well, that’s completely different. First of all, it’s important to understand where Vitamin C is synthesized from, and this is. What’s the problem with vitamin C as a whole, first of all, is its pH levels when we talk about vitamin IVs. And the second thing is, again, how Vitamin C is both an antioxidant and a pro oxidant. And when we are using a high dose of vitamin C ascorbic acid, it actually can make iron atoms in your mitochondria and kind of in your intracellular membrane. It can make them excited, it can actually destabilize them. And that can cause basically free radicals that are extremely damaging to the cell but to your DNA specifically. So that is why a product like Ace that one thing would be if they’re like super fresh, and you get, you know, some high high level of sorbic acid IV, but if you’re talking about and it’s it’s equality one, that’s one thing, but if you’re talking about a skincare product, that an average age of a bottle that you’re buying at fill in the blank at a store is two to five years old that vitamin C was made two to five years ago. Wow. So you can imagine how unstable it has become. And by the way, in the world of skincare products there’s a lot of chemistry that’s going on with balancing pH and things like that, which is like acidity. So it needs to be equivalent to yours, your skin’s acidity for that matter if anyone remembers 20 years ago, there were like, you know, soaps that were like pH natural and stuff. So that’s kind of connected to that. But to get to my point about vitamin C set synthesis. The reason we do want to use vitamin C, magnesium ascorbyl phosphate is called Map vitamin C, and another version, it’s called THD ascorbate. These two versions are really really good in being kinda pH natural things like that. If we want to talk about something we take orally, it could be sodium Escobedo calcium asker bathe in these things are really, really good in again, upping the ability to resist the damage from the sun by let’s say, SPF three. Okay, right. And by the way, just as an anecdote, high, kind of high level sunblocks that you’ll buy will have an antioxidant within them. And that has been shown to double their efficacy. So just to connect to the same idea, okay, the third one, which is, again, we’re talking about not necessarily resisting sun damage, we’re talking about vitamin D synthesis, the third one is actually using lanolin on your skin. Hmm.

Dr. Mindy Pelz  

Okay. So this again, just so we’re clear, this is if you want to go out in the sun, and you want the most to get the most vitamin D, but you don’t want skin damage, so you’re increasing your chances of okay, go ahead. So

Amitay Eshel  

lanolin can double the amount of vitamin D that you’re synthesizing. Wow. And again, just supplementing and K to vitamin k to k one and k two can increase your ability to create that vitamin d3 that you want so much. Yeah. So again, like you know, we talked about well, there were there. There is another molecule specifically in skincare, you’ll see it’s called egg coin. It’s a type of protein. It’s really cool because it’s from Have you ever heard about water bears or space bears? They’re called sometimes. No, they’re extremophiles. They’re micro, very, very, very small organisms, they look really cool. And they have the ability, they have this protein, and this protein structures water around their proteins. And it kind of creates like a buffer that that proteins can get dumped and damaged as well. And that is something that we’re starting to see in skincare more and more, we actually used it for the first time like four years ago. And we were like the only company who used it. And it was very difficult because the cost of using it was really, really high. Now there are entire skincare brands that are based on EC toys, mainly in Korea and stuff like that. But this is a really good product to use in order to protect yourself not only against UV damage, but also against EMF against, you know, heavy metals, pollution, artificial light, blue light. Ashwagandha is really good to protect the skin against artificial light and blue light. So

Dr. Mindy Pelz  

yeah, so talk about light, because then there’s sunlight, there’s blue light, and there’s red light. And I have an eye here in the conversation of skincare, all three of those use differently. So let’s start with blue light, because we just addressed sunlight with like, we’re I’m on my computer a lot throughout the day, that blue light coming off my computer is damaging my skin significantly.

Amitay Eshel  

And it doesn’t only damage your skin, by the way, yes, it damages your skin. And all of the skin types, which I would kind of maybe categorize you within that little, you know, enclave are actually the most susceptible to that type of skin damage, just the way that this wavelength resin resonates with you with that pigment. So actually, that doesn’t only damage your skin and your collagen, it actually also damages the ability to synthesize collagen. And what I’m saying right now, it’s not like we’re gonna literally have our skin melt off our face once we sit in front of the computer. But again, we’re talking about increments here. And sitting in front of the computer, why is it so different from having a blue light that is part of the makeup of the sun, it’s because of two, two reasons. Number one is the percentage of it. And the second is what we call HEV which is high energy, visible light. So these photons which are particles of light slam into your skin significantly more powerfully than what they would in a natural circumstance. And that is really bad for your skin, by the way, so some of the things that I said are very good to protect. Yeah,

Dr. Mindy Pelz  

yeah, that was gonna be my next question. So what do I do so now I’m staying out of the sun to get knots helping, but I’m sitting at the computer all day so I can take those same supplements you talked about is there anything I can put on my skin or yes filter on my computer to block that that bad blue light from damaging my skin

Amitay Eshel  

100% So first of all, in most electronics today, there is a there is there are things that you can do to the actual screen to have less blue light. So if anyone has like an iPhone, there is a setting that allows you to completely like with three clicks on the side of your phone to have it completely red, completely rare. And not only in the night shift which makes it slightly yellow but also completely red. And for the most most part of the day. That’s the configuration my phone is at computer kind of the same thing we can definitely buy a nice kind of screen protector type thing. But there are a lot of things that you can do to the actual screen. Now to the actual like makeup of colors that come out of the screen. Having said that, we can definitely put things on our skin for example echoing for example, a really cool antioxidant that is called lipo, Chrome and six again, pretty expensive skincare ingredients so aside from us, I haven’t seen it yet in skincare, but this is very similar to C 60. If anyone knows C 60 Although C 60 actually makes you a little bit sensitive to the sun. This makes you less sensitive and also less sensitive to the to the blue light. And again ashwagandha which sometimes in skincare you’ll see it’s called Winter cherry is also a really good ingredient to protect against blue light. And you

Dr. Mindy Pelz  

guys I you have a product called Bio shield I think is that what is that meant to block you block the EMFs correct

Amitay Eshel  

that actually protects the blue light. We said you know again like who We’re a biohacking skincare company, right where we claim that we’re the most innovative skincare company in the world. So when we go and research a product, and again, I mentioned like we started using Exxon four years ago, it’s already five years ago, it took us four years to develop our sunblock, everything there would have a little bit of a peculiar way of, of addressing so anything from our like, the way we use zinc oxide is really special, we process it differently than anyone else, which makes it like, doesn’t leave that white, little powdery look, but it protects you like much better. We also have that Ecto in there. And we have like Prokom, and six. And we also have a blend of herbal Chinese herbal extracts that allow us to protect better against EMF and pollution and heavy metals. But it’s very, again, it’s we call it a 360 degree environmental protection, because I’m going to drop a bomb over here, you if you’re living in western world, you age about 80% of the skin aging isn’t caused from what we call intrinsic aging from the way you eat, from the way you you, your body ages naturally. But it actually is caused by the environment. And within that 80% More is driven by other things rather than UV. So the things that I mentioned, like glyphosate, it’s pollution, again, artificial light, dust mites, all of these things together are together, driving more of skin aging than UV. So when we designed a sunblock, we’re saying, Okay, that’s great, we could just make a product that is going to be great. But it’s going to be another product on the market, or we’re saying let’s see what’s really happening here. What are we really protecting against? A little bit harder to explain, but the protection is much better. And we are getting like a lot of people saying, you know, I’ve never had a sunblock like that or something like that, because we address things a little bit differently. Yeah, different. Oh, that’s

Dr. Mindy Pelz  

beautiful. Talk about red light. So we, you know, there’s a lot of red light masks. You know, I have a red light in the morning that I put on when I meditate or I turn on when I’m meditating. Is it true that these red light strategies can repair collagen?

Amitay Eshel  

Well, they can definitely support the repair of college and they are not well, that’s I’m gonna risk losing like one person listening, if they don’t want me to get a little bit nerdy on it. But I really want to explain something. So first of all, why do we react with red to red light anyway, remember, I told you before about the angle between the Sun and Earth. So basically, the more atmosphere, the wavelengths of light pass through, the more they get absorbed in water. So what we’re left with are wavelengths that are not absorbed in water very well. And because our body is made out of water, mostly, they can actually travel through our body with ease, okay, and that’s why we’ve, through the ages, we’ve evolved to interact with those wavelengths, they are predominantly like red and near infrared, which is different than far infrared, that that is used in saunas, because that again, the way it warms us up is by interacting with with water with by friction with water. So it actually isn’t a very good therapeutic method, if you would, but red and near infrared, they are our body, the mitochondria evolved, so the powerhouse of the cell evolved to interact with them specifically, which is super cool. So only like this one enzyme in the mitochondria absorbs this light, the red light, the red light, and near infrared, which I like to say it’s red that you cannot see, don’t think about it as infrared. Just think of it as red that you can’t see because they interact in a very similar fashion. But the way they interact is through stimulation, which means that there is like a lower threshold and an upper threshold. So a lot of the things like these masks, I’m not saying they’re not good in general, you’re just working, it’s like working with very lightweight in the gym. And a lot of the things that we think of as the most powerful ever blah, blah, there really is no need for that amount of power, the ability to stimulate the mitochondria is pretty substantiated. So 99.9% of the panels such as the one that you mentioned, will work and they’ll work very well. It’s a little bit challenging for an industry that tries to differentiate itself. I’ll give it I’ll give the industry that but for the most part, any panel that you’re going to get works very well. Now I said that it supports collagen production and the reason is because my body, your body, anyone’s body doesn’t know that wrinkles are a problem. It doesn’t know I pigmented hair. areas of problem it doesn’t know, a lack, you know, lacks skin is a problem. That is because there is no direct inflammation that is created there. It is more as you can think of the way that the Earth doesn’t know that a mountain or a valley is a problem, right? It’s just there and it’s now we work around it. For the most part, okay, we can improve hydration, etc. We can look better, but the wrinkle is that dividend collagen isn’t something that the body has on its agenda to repair. So even if we support the powerhouse of the cell, even if we support, more energy, more ability to repair, we have to have something else that stimulates the repair of that wrinkle alone, it will be very minimal, the effect will be very minimal, because we haven’t done anything to signal to communicate to the body. And that’s kind of going back to kind of the first thing we ever said in this conversation, which is like, oh, we have to communicate in a different way with our body. Once we’ve passed. You know, 41 we’re, once we’re flirting with perimenopause, and obviously after, you know when once we’re in menopause,

Dr. Mindy Pelz  

right? What about sweating, so you brought up infrared. And what I’ve noticed is that there’s two things where I can really do bio hacks that I can really see a difference in my skin. One is an infrared sauna. And the other one is actually a hyperbaric oxygen chamber. And I’ve done a lot of research on hyperbaric but it seems like when I do both those bio hacks on a regular basis, my skin definitely has a different look to it. So is it we’ll talk a little bit about the importance of sweating, and not everybody has an infrared. So is it maybe they just need to sweat more often? And then what do we know, I know you guys have a hyperbaric mask, which is really cool. But what do we know about needing oxygen on the skin? Well,

Amitay Eshel  

So we need oxygen in order for our skin to have it’s kind of related to the last thing we said, which is that the skin needs energy in order to repair. But I’ll go, that’s just to answer your question, that will go back to sweating. And one of the things that the skin is working against is obviously toxins and the inability to alleviate toxic load. So what you’re seeing basically is a more refreshed skin. And another thing that is called Skin autofluorescence, which means how much kind of infrared you’re emitting and which our eye receives as a glowing, beautiful skin, which is different from shiny. Again, not there’s actually no relation between the two. But that vitality that kind of jumps at you, okay. Now, another thing that infrared is really good at is HSP show heat shock proteins and these proteins, which happens also, by the way, when we’re in cold plunge, they’re actually the same proteins, but that he he chopped proteins, what they do is they go back, and they look at basically proteins that weren’t built well, and they can kind of use those proteins and build them rebuild them. It’s like you have a kid that built a Lego Castle. It’s kind of weird. And now there’s no door and a window. And you know, it doesn’t do what the Lego Castle is supposed to do, or whatever, you know, and you kind of go back and you fix a few things. And now all it looks like what Lego intended. Right? So this is what p Chuck proteins can do. So that’s something very interesting. But again, we are missing a piece, which is kind of the rejuvenation piece, if you will that signal for repair hyperbaric is a little bit different because a lot of the signals are not necessarily from that oxygen, but from the oxic hypoxic hypoxia effect, or the effect of us having a lot of oxygen loading our cells with oxygen and allowing a lot of energy to be created. And then tricking the body to think that it doesn’t have a lot because we’re getting out of this, the hyperbaric chamber hormetic stress core 101 100% We can see it across the board. A lot of the a lot of the pathways that were interested in, when we talk about hormesis whether it is like sirtuins to TNF I mean a lot of them any type of like detoxification pathways, they are all being activated by this hyperoxic hypoxic paradox, which we call basically when we’re when we’re getting that shift. Yes, yeah,

Dr. Mindy Pelz  

It’s like metabolic switching with food and fasting. So going in and out of oxygen. It creates that yes, yeah.

Amitay Eshel  

No, you’re so correct, because sometimes we see how the body actually kind of does the same thing by completely different stimuli, right. So there is a type of oxygen of stress that has an extremely short shelf life that is being expelled kind of from the mitochondria, and stimulates repair, reduction of inflammation, things like that. In both cases, we see the movement of reactive oxygen species, which are very, very short lived, and they’re very good for you.

Dr. Mindy Pelz  

Okay, what about fasting? So something I noticed when I first started fasting, was that, that you called it something photo essence? autofluorescence? Yeah, auto fluorescence, okay, yeah, when I fast I swear, my skin gets a more orangey tinge to it, it looks healthier, it’s just not in a bad way. It just has more color. And I used to in my clinic, I could literally tell when somebody would walk in the door, I would look at them and say, what, how long of a fast are you on right now? Because there was a shift that happened in their skin that made their skin glow? Does it have to do with what it means? What is going on in the skin? Basically?

Amitay Eshel  

Well, first of all, before I answer the fasting question, I would say probably some of it is due to the fact that you’re still drinking water. And you’re taking, you know, plenty of sodium, which allows, you know, for water retention, so that’s part of it. And that should be a part of I mean, that’s great. As far as like, again, having, you know, being in a fasted state, we’re getting into one of the key players in skin health, which is autophagy, which is the ability to

Dr. Mindy Pelz  

favorite word, my favorite.

Amitay Eshel  

Well, you know, autophagy, so a lot of the times we talked, I talked about those verticals, which are called the hallmarks of aging. But a lot of the time we’re thinking of them as completely separate divisions. But it’s a ditch, it’s not really the case, because what we’re seeing is that autophagy for example, is a vertical is a name for a type of aging process that is happening that is affecting 75% of the other verticals. So it affects for example, senescent cells or is effects for example, protein misfolding, which is what I referred to, by the way, before, when I said about the heat shock proteins, or effects, intercellular communication, nutrient sensing, it affects a lot of the same things that we’ve given other names. And by doing that we can, it is a master regulator of aging, if we want to master regulate our age, we normally don’t want to do it or the if we zoom out, and we want to have something that affects our whole body, we normally don’t want to talk necessarily about the hormone that we need to take a peptide that we need to inject or apply, or whatever, we want to look at processes that are kind of like mild stress to the whole system, like temperature, like you know, nutrient deficiency. So these things, as long as they’re controlled, they actually do magic because they not only don’t only interact with one system, they interact with multiple systems. So

Dr. Mindy Pelz  

if I, if I decide, I mean, the thing about skincare that also is challenging is it’s very expensive. Yeah. So if I decide, hey, I’m going to really invest in a high quality skin care product, what I’m hearing is if you want to amplify the benefits of that it is stimulating autophagy on a semi regular basis. It’s it’s the driver of all the other skin enhancements that you’re looking for, I

Amitay Eshel  

would say yes. And what you’re saying is an extremely advanced way of looking at skincare that very few people are talking about, I would say the only person that ever raised that aside from you is Dr. Amy Kailyn. And that is so what we want to do is to have basically a push period and a which means in an anabolic period, which means period where I nourish and remember that hyperoxic hypoxic paradox. So a time where I actually kind of nourish the skin the most, the most that I can and kind of push it to do the most, use those simulations, like micro needling, like retinoids like we can talk about those but really stimulate repair, ask for repair. And other times it’s like, you know, let’s say we’re now in a holiday season and young goose right, so we have, you know, 1000s of orders that are coming in. The problem is that that creates a lot of waste. You can imagine how much like the end of this is there. And if we would have never cleaned our production facility or shipment facility, no one will be able to move right. So there has to be periods where we’re producing and we’re giving everything that the production needs, all the raw ingredients, whatever that is really you can think of. My factory is an example for that. Yeah, it’s a great analogy. And then there has to be a few times where we’re cleaning up and both kind of feed off each other. There won’t be anything to clean if we don’t have work and vice versa. The same way when we’re talking about the skin, this is, by the way, one of the most fundamental processes that cells have evolved to, from the literal beginning of time, that interaction between a push period and a repair period or recovery period is literally in every cell in this galaxy. Yeah,

Dr. Mindy Pelz  

It’s I mean, it’s the fundamental principle of fasting which is to dip into a semi stressed state to heal your body then go back and nourish it and I love what you’re saying is we got to look at everything like that. So Okay, talk about this is this is to me is the elephant in this menopausal skin care room, which is Botox? I’m not gonna lie, it would be really nice to just inject some Botox in my forehead to just smooth everything out. But I am always thinking about myself 10 years from now, 20 years from now I think of my toxic load often. So it scares me to put a you know, a poison into my body to change, temporarily temporarily change my skin, but I’m willing to be wrong. So what are the things we need to think about with Botox? Is it a good idea? Is that a bad idea from a skins perspective?

Amitay Eshel  

Well, if we’re Puritan, then I would say it’s a bad idea. But we are, where we’re not. So I am not in the business of telling people what their decisions should be. But what I am in the business is supporting those decisions in the best way possible. And it’s not lip service. I, you know, I really, truly believe that if Anastasia, my wife decided to do Botox. Obviously she won’t ask me even but I won’t tell her no, what I would tell her is that and that’s something she knows already, because she’s the biologist. But what happens is that we are getting a few different types of things that are working against our health, when we are doing Botox, by the way, fillers are different, as far as their chemistry, and they work a little bit different. But one thing that is again, happening in both is the inability to clear toxins, which we talked about before, which is the lymphatic drainage aspect. And that is super important because the way that the lymph lymph system works and the fabric system works is by contraction of muscles. Obviously, also by differing G forces. So when we walk, or anything like that, but really what it’s predicated on is good contraction and release of our muscles. And if we freeze the muscle, you can see the problem there.

Dr. Mindy Pelz  

The toxin stays, and there’s no limp movement.

Amitay Eshel  

Yes. And what worked and that’s one thing. The other thing is the fact that not when we are going for our next Botox injection, which if you look at the internet, if people try to scare you, they’re going to say, Oh, you need to do it every six weeks. No, you can also do it every six months. Okay. So really, truly, you can just do it twice a year. So when you’re going for your next Botox treatment, not the entire toxin is out of your system, some of it is still there. So you’re kind of topping off. The problem there is that we’re constantly dealing with that toxic load. One thing that we can do to kind of alleviate both, well, first of all, zinc helps. Okay, having more you get a for General, General having adequate amounts of zinc. And by the way, topical touring or Toray are also very, very beneficial. But what we’re really thinking about is that it doesn’t stop the aging process, our skin is still aging in the background. So that cannot be why a lot of people are saying, If I’m choosing Botox, I don’t need to do it, I don’t need to do maintenance, I don’t need to have a skincare routine. That is the problem. The problem is not supporting your skin’s aging process. In general. The problem is that you always will need a little bit more Botox to get the same result next time so it builds up right. And the problem is that you don’t have any toxin removal or very limited toxin removal from those cells from that system. So one of the things that we can do to tackle that is to have a lymphatic massage or like a facial massage, if you will, doing facial yoga. All of those things are very beneficial, especially towards the end of the last 30% If you would have your journey with Botox whether it is every four months, six months Whatever that is. So we have to understand that our muscles definitely need some kind of care and maintenance, because we’re freezing them you can imagine again, sorry for the example and imagine someone in the hospital that cannot move their limbs, the hospitals moving their limbs for them, there isn’t an entire industry of of ways to move the body if the body cannot move itself. So, that is something that is super, super, super important. And there are other things coming in the pipeline of those companies, that would be more mild as far as toxic lung, die sport is one of them is another type of injection that is similar to Botox because they said fillers are not the same, right. So sport is one of them. As far as filler fillers are concerned, also, fillers are changing significantly. They also have the same problems, one of the problems that fillers have in these not completely looked at is a bonus that can lower with both hyaluronic acid fillers, it is a problem especially because we’re doing it next to our our jaw or our you know, again, we’re fitting, again, our our bones that are closer to the surface of the skin. So this is a little bit of an issue. Again, you want to try and do it very seldom, if you do, yeah, and there are now also options to have fat grafts. So they take a fat from your abdomen, again, something like that, and they inject it, there is a lot of risk for infection. So that is something again, this is super super individual between doctors how they do it. But that is something that you should look at. Lastly they would say there are people who take V cells, which are very small embryonic stem cells and reinjected back into the face, you it’s very expensive. And you need to do it very often. But if you are one of those people that can afford it and has the time to travel and get it done, that could be something that is going to replace all of all of those things.

Dr. Mindy Pelz  

Interesting. Okay. And then, you know, last year, I really wanted to dive into understanding things like and spermidine. Things that we actually talk a lot about in the fasting world are now sort of appearing in the skincare world. So you know, I went through the whole NAD IV four days in a row I’ve been doing one a month I really liked that I’ve been adding in some spermidine in my fasting window to enhance the the effects of a toffee G and then I met you all last spring and you’re putting these things in skincare. And this is really so my audience knows this is such an authentic comment I’m about to make. I have looked at a lot of skincare through my pre menopausal years and something you’re doing with your skincare, I had the most impactful change that I could see. I’m more interested in what I see. Yeah. And I’m curious what these NAD boosters and the you talked about a spermidine product you’re coming out with fascinating that serum I put on my your serum, it’s a game changer. So talk about what is in that and why we would want to think about NAD and spermidine as a topical agent, not always an oral one.

Amitay Eshel  

Well, fantastic question. And that’s funny where the same comments I made before about reactive oxygen species kind of living or is a reaction in our body to different things actually exists also when we talk about NAD in the aging process. So when you are doing NAD IVs your body does not prioritize the skin anymore like the skin is literally the last thing in its list of Oregon’s to replenish AND four. By the way, same thing with supplements. So even if we are doing the utmost advanced protocol up to the most advanced protocol for NAD replenishment, we are not going to get a lot of NAD in our skin and why do we need an ad in our skin? It’s because I did mention sirtuins which are I call them the police of the DNA they make your DNA behave correctly. But we also have another set of enzymes and another family which is parks which I call the fire department of your DNA. And just think of a world where there’s a lot of fires who is going to get more of the budget you’re or more of the fuel to get from place to place right there is definitely looting that is happening but let’s first take care of the fires and that’s really what happens in the world unfortunately. But the same thing about NAD replenishment in the skin, as we said in the beginning, as we grow older, is the unrepaired damage of the snowball effect of aging that is happening in the skin really soon. starves your the enzymes that are basically in charge to make you keep your young, they starve them off of their food, which is NAD. So we have to, we just have to replenish it topically. The problem is that NAD is a molecule, there are very, very few molecules in your body, which you can give them in the same form for which the body uses them. Even if we think of protein. And let’s say collagen protein, there are so many ads now for collagen protein and how it’s good for your skin. It’s not necessarily that the collagen protein is good for your skin, it’s what your body is doing breaking it down into building blocks, which then it uses to make collagen. So that’s across the board, something that we need to understand. So if we take any D supplements, if we take NAD IVs, by the way, the reason you flush when you get an NAD IV or that you have a bellyache, it’s because of the body kind of breaking it down. And some of those adenosine, some of the one of the things in NAD is making you flush. So what we need to do is use molecules which the body knows how to use in the right way, which are the building blocks for an ad. So we’re making the whole trip much shorter, instead of giving the body an ad, the body kind of breaking it down. And then, you know, using these building blocks to build an ad, again, we just give it the building blocks. And that’s what we did in skincare. And that’s why it’s very unique. So we were the first company that ever did it in skincare. Yeah, I saw that. And we’re starting to see a lot of companies doing the same thing. But because they are following the demand. And they don’t go through like seven years of development that we did, because you don’t you can’t afford seven years of development. If something’s hot right now, you can’t say oh, I’ll have it in seven years. What they do is they just put pure AND there, which doesn’t absorb into the skin and has no idea how to absorb it, it’s also too big. Or they put you know, the kind of things that are supposed to boost NAD. But there, again, because they’re topical, they don’t communicate with the whole system, and the body doesn’t work like that. So by now we are looking around and we see that people still haven’t kind of gotten away from replicating what we do, which is legit boosting, doubling the amount of NAD that your skin has where you apply it. And by the way, that’s something also important to remember that even if you have the NAD IVs, and your body somehow magically decided that it wants to prioritize your skin. Where is it prioritizing? Is it prioritizing the skin on the heel on your neck? How does it know? How does it know that your wrinkles around your eyes are the ones that it cares about? So we want to apply it locally. That’s number one. And also we need to have something like resveratrol, for example or Tilly roadside, which is another polyphenol, or taro stilbene, something that would if NAD is the fuel for all of those repair processes, we need something to press the gas pedal. So resveratrol is very, very important as well. We’re, you’re correct to say that we’re going to be the first to introduce spermidine into skincare. We see other companies doing it as well, by the way, so if you don’t like Yun goose, don’t worry about it, there will be other companies pretty soon. But this is something pretty cool, which we’ve been experimenting with. Actually, we’ve had it in a few products, like our cleanser, like our care moisturizer before but in a very, very small amount. Because we were only researching how to really get it well into the skin and to have it have the skin use it well. And we figured it out. And by the way, a company that helped us tremendously and is kind of our partner in this is longevity Labs, which has for me the life. So for the last two years, we’ve been developing this skincare product that still has our NAD precursors, still has some incredibly cool peptides that we’ve developed like a system of peptides, but also spermidine. And what we can do is not only that we can support fasting, which you mentioned, the skin looks really good when you’re fasting, but we can mimic fasting which is ridiculous. So we can mimic only the regenerative parts. We don’t mimic fasting by the way that we starve the skin of nutrients or calories. We’re only mimicking the part of activating autophagy and activating you know, NAD synthesis and all of the good things that are happening during fasting even when you’re not fasting. So even in your quote unquote push periods where you’re stimulating a lot of repair and renewal. We’re also getting those processing processes along the way, which I think is really cool. It’s

Dr. Mindy Pelz  

super cool and I love stacking Different bio hacks. And I’m thinking with this new product, knowing that spermidine activates a toughie, G and if you’re in a fast longer than 17 hours, you’re stimulating a toffee G. So it would be a beautiful way to just keep that, like you said, the push period, allow your your everything from your internal organs to go through this, a toughie G repair, but your skin, like you said is the last thing that it’s going to repair. So that you may have just amplified the effects of fasting by allowing us to put it on topical. And, you know, personally, I would say you put it on in the fasting window and just get it, get it all to amplify. Yeah, and then just make sure you’re eating really good food when you go into that eating window. So what I hear you saying is you can put it on while you’re eating too, and you’re still getting a toffee G on the skin. I just liked it. How do we amplify a toughie G as best we can 100%

Amitay Eshel  

And that is the real difference between an amateur Skin Rejuvenator and a professional in our you know, that’s something that again, we had a consultancy for, like biohacking brands, and a few really big brands that have been sold by now. And what we were what we used to tell people is that you always have highs and lows, but you want to shorten your lows and increase your highs, right. And that can be applied also here, what we want to do is, obviously there are going to be times where you are stressed in life, there are going to be times where things are not going to be good. You’re not gonna get sleep, you know, we’re expecting a baby. So I’m sure we’re getting into one of those that’s talking

Dr. Mindy Pelz  

I want to know about your wife, skincare regime and a year. Yeah,

Amitay Eshel  

for sure. But you want to be a professional, you want to make sure that you are understanding when you can push your skin to do more when you can ask it to do more. And also when you want to just support and kind of replenish it and leave it alone for a second. Yeah.

Dr. Mindy Pelz  

It’s so beautiful. Okay, before I ask you my last question, I got to make sure that we didn’t miss when I asked you about sunlight. You said it’s not the number one thing you need to be worried about. What is the number one thing we first skin that we need to be worried about?

Amitay Eshel  

I would say carbon and nitrogen free radicals. So free radicals that are caused by pollution, things like gas exhaust, car exhausts, things like that. Our skin is clueless as far as how to deal with it. It has no no innate antioxidant that is dealing with it again, like we can do a few things. C 60 is really good internally. But the problem is it does make you a little bit sensitive to the sun. So yeah, better to take it at night, if you want to have that dance going very effectively. Especially if you’re doing high doses, especially if you’re, you’re using like, I don’t know, something like wizard sciences, something like that. It has a lot of 60 and you’re full of it. But another one is lipid Chrome and six, which is very, very similar. It’s just applied topically and it mitigates a lot of those bad, you know, parts of, of antioxidants. Yeah, yeah.

Dr. Mindy Pelz  

Or move out of a city that has a lot of pollution. I unfortunately grew up in LA. So that was working against me. And then I live in the San Francisco Bay area. So that’s still working against me. So what I hear though, is then it becomes even more important. So if air pollution is the number one skin damage we need to really address that through the strategies that you mentioned.

Amitay Eshel  

unfought Yes. 100% Unfortunately, I wouldn’t like to say to you people who live in Alaska, or I don’t know, we talked to Brock before the air. He’s in Vancouver Island. I

Dr. Mindy Pelz  

don’t think he Yeah, he doesn’t have a lot of pie. So I would

Amitay Eshel  

I still say these are things that you need to look at. Because a lot of these things rise in the atmosphere and with rain with lowering of temperatures they occur, they kind of circulate back down. And we want to exactly, unfortunately, but the good thing is again in the biohacking Community Health optimization community, we know that we can do things to mitigate that. So yeah,

Dr. Mindy Pelz  

amazing, amazing. Well, again, like I said, I have tried a lot of products that are all natural. I’m always because skincare is just, I mean, we don’t even need to address this. Hopefully people know it, but I think it’s important to understand that a lot of skincare are their endocrine disruptors. So here you are in your 40s and 50s trying to balance your hormones, hormones stay young and what you’re putting on your skin is actually causing hot sweats and weight gain and mood disruptions. You don’t even realize it in your attempt to stay young. So when I wouldn’t give me the NAD product first I was really clued in to NAD at that time, and I was like oh for my skin that makes sense. And then after a couple of months of using it, I’m sold like I’m totally sold. So I just am so grateful for you know, your knowledge on this, you guys created something phenomenal. So,

Amitay Eshel  

and I would say one thing is that we’re the only company that I’m aware of at the moment. And again that I’m aware of that is creating what is called homeostatic skincare. I don’t believe in the word clean, I believe it’s a large umbrella that you can really have murky waters there. What is clean is good, what’s bad, what we test is literal people and we make sure that we are not disrupting their endocrine system. So that’s what we call homeostatic skincare.

Dr. Mindy Pelz  

I love and so if somebody was to use your products, what’s the easiest door? And like, Are there two or three products they should start with first? Yeah,

Amitay Eshel  

The products that we covered are a good start. So pro care is the serum, it mainly deals with senescence cells, we have care, which is the moisturizer, and we have the hyperbaric mask. So this is this, by the way, kind of turns the moisturizer into a night cream, you just apply it over the moisturizer and leave it overnight. You could do it every night, you can do it once in a while, whatever you want, the results are crazy. I would say that, you know, keep your ear to the ground. Because in a couple months, more or less we’re going to have our Dalian youth reset their serum and moisturizer that they’re going to have also the spermidine and stuff like that. So until then you have this. And you know these Yeah,

Dr. Mindy Pelz  

yeah. Well, I’m gonna tell you, I thank you for having this conversation. I, you know, part of where my heart is at is giving women natural, safe ways to take care of their health after 40. And skincare is such a crazy conversation, and everybody has an opinion on it. And what I am very, very dedicated to doing is not toxifying myself to stay young. Yeah. And this is why you have created a solution for so many of us. So I really appreciate that. And I know you’re giving. I think we have 10% off. Yeah, your products for those of you that and the code was

Amitay Eshel  

DRMINDY for 10% off at younggoose.com

Dr. Mindy Pelz  

I love it. So we’ll leave the code down there. And you guys can get 10% off your first order. And I have to ask you my final question. And I love knowing what people’s superpower is. So if you had one superpower that you think you would bring to the world, what is it?

Amitay Eshel  

Love to help? I love to help. That’s my hobby. I didn’t like the fact that I’m a sucker for helping people for a long time. But I’ve relinquished any resistance that I have in the last couple of years. If anyone needs my help, they can let me know. And yeah.

Dr. Mindy Pelz  

Yes, that’s such a good superpower. And now that makes sense that you were like, the first time I think we actually met was at one of the biohacking conferences, and you were like chasing me down with you with one of your products. And I was like, you just gave it to me. I was like, Wow, it’s so sweet. Thank you. Let me go home and try it. And I’m gonna say that, I definitely feel that from you all. And part of what I’m committed to doing is really supporting companies that are heart based, too. So I just appreciate you and thank you for enlightening us. And yes, keep us posted on anything new that comes out. I want to be the guinea pig. Sounds great. Great for you. Thank you. Thank you so much for joining me in today’s episode. I love bringing thoughtful discussions about all things health to you. If you enjoyed it, we’d love to know about it. So please leave us a review, share it with your friends and let me know what your biggest takeaway is.