The Vital Role of Ketones in Metabolic Health, Brain Function, & Fertility – with Latt Mansor

Dr. Mindy  

On this episode of The resetter podcast, I bring you dr lat min sore. Now a couple things to know about Dr. lat and the conversation you’re about to hear, for starters, we’re gonna get dive deep into the concept of a ketone. So Dr. Lat holds a PhD in physiology, anatomy and genetics from the University of Oxford. So he is brilliant. And he has really mastered the use of ketones when it comes to performance. So I love this conversation on so many levels. Because A, it gave me some new insight into how we might look at ketones and and its effect on all aspects of our life, not just our health, but be what Dr lat brings to us is what we call an exogenous ketone. And an exogenous ketone means that you actually are not producing it on the inside of your body, you’re actually taking it from an outside source. Now, in full transparency, I want you to know that I have typically been against exogenous ketones, but Dr. lat, he has changed my opinion based off the science that he is bringing us. So if you’ve been one of those people who have messaged me have wondered about exogenous ketones, where do they fit in? This is the conversation for you. There were a couple of my big takeaways on this, one of which is how we can use exogenous ketones in the Fed state. So this isn’t in the fasted state, how do we eat a meal, and then use an exogenous ketone to help stabilize blood sugar? That blew my mind. I also loved how he looks at ketones for recovery from exercise. And then as I said, How can we lean into these exogenous ketones for just overall performance in our day to day activities. So Dr. Lappe completely changed my opinion of exogenous ketones, and you’re about to hear why plus for all you science nerds that want to know the research, Dr. Lat will bring it to you. So enjoy, this is definitely a conversation that was needed. And I’m so excited that I got to have this with Dr. lat, because not only as you will see, he’s incredibly brilliant. But he also has a huge heart. He’s on a mission like so many of us, and he is reinventing the way we all look at exogenous ketones. So with that, I will tell you enjoy. This is an incredible episode.

Dr. Mindy  

Hey, Dr. Mindy here, and welcome to season four of the recenter podcast. Please know that this podcast is all about empowering you to believe in yourself. Again, if you have a passion for learning, if you’re looking to be in control of your health and take your power back, this is the podcast for you. Enjoy.

Dr. Mindy  

Okay, and that you’re my first in Person guest of the recenter podcast after like hundreds of episodes, you’re the first

Latt Mansor  

thank you so much. It has been such an honor. I interviewed you a while ago on hvM a podcast and now we’re making this happen in person and to be the first and I didn’t even know by the way. I didn’t even know that I was the first one it did today I came in. So

Latt Mansor  

yeah, you’ll always be the first I will always I claimed it you heard here first. I will be the first Yeah, it’s really exciting. Because I can tell you that connecting with people is like a massive value for me. And zoom just doesn’t do it. Yeah. And I like to be able you and I have spoken on Zoom before but to be in your presence to feel your vibe to have this conversation we’re about to have is like this is my jam. I’m having goosebumps because I I know how energetic you are when you talk and I think part of your success is also due to that energy and how passionate you are. It comes across and I remember meeting you last year, July in Quito con Yeah, that was the first time because that was through Ben Azadi through Cydia Thurlow. And Ben also have you met met Dr. Mindy Pelz. And that was when I was like, oh my god, I look up to these people because the only last October that I started podcasting. So I’m still You’re very good. I really thank you. Yeah, you and I had like really geek out conference. I know we did. I all the science knowledge helped a lot like my background really helped me interviewing, you know, clinicians

Latt Mansor  

Doctors and all that they experts like yourself. And you know, but the fact that you, Ben and Cynthia Thurlow, like the trio that always give talks everywhere and do your own podcast that really inspired me to really do well by by my podcast by hmm, podcasts, but also do well by the audience because it’s ultimately what the audience wants to hear and want to learn because they are people, they’re always going to be people out there who is so curious, and really want to learn about metabolic health and learn about their bodies better.

Dr. Mindy  

Yeah. And, you know, to that point, one thing that’s really emerging for me and in the world that I’ve been in with launching Fast Like  A Girl into the into the world, is that we need conversations around the information. When we look at health, one of the challenges we have is we go black or white, you know, a ketone is good, or it’s not good. You know, it’s very like you want your numbers to be this, you don’t want it to be that. And the human body doesn’t work like that. No, it

Latt Mansor  

doesn’t metabolize, I tell people all the time, metabolism is not a straight line. No, it is a flux, it’s always ongoing. And you need to keep it in the Goldilocks zone is the optimal level of pH, optimal level of temperature, optimal level of amount of hormones that you’re going to be in amount of enzymes, and you’re going to be in. Just because something is good doesn’t mean that more is better.

Dr. Mindy  

Exactly. And to to that point. I feel like one of the challenges we have in the biohacking world is we understand something new about our body. And this could be something as simple as like, we just discovered our hormones like testosterone, all of a sudden, we’re like, I need as much of it as I possibly can guess. No, no, you want to always be bringing these things into balance. And that’s where the body really shines. So with that in mind, where I want to start this conversation is, what is the ketone? Because there’s so many people chasing ketones that don’t even know what it is.

Latt Mansor  

So ketone is the brain’s super fuel. Okay, why do I say it’s a fuel, it’s the same as every other form of fuel. You know, in the, in the human body, we know the fuels are carbohydrates, fats, protein to a certain extent, of course, our body will always try to preserve protein till the last bit. So mostly, we’ll be using glucose or fat, right? ketone works the same way. So ketones are broken down from fat getting converted from fat in the liver, and enter the Krebs cycle the same way glucose and fatty acids would and provide ATP, which is the energy currency for the cell. Right? Then a lot of people ask, why do we have so many different forms of fuels? It’s because a good question. Yeah, it’s a good question. Because different situations would require a different form of fuels. So when we use glucose, it’s when we need fast fuel. Because glycolysis the first part of glucose metabolism, you don’t need oxygen to create that. So when you do intense exercise, when you go on an aerobic exercise, you will burn glucose first, for fat fats account for 20 to 40,000 calories of storage in our body versus 2000 worth 2000 calories worth of storage of glucose. So fat contain way more energy, but it’s harder to burn. So when you go on endurance race, when you go into cardio zone to that’s when you tap into your fat storage. Now, I know you talk a lot about this on your on your podcast, when you are on a carb restricted diet, I eat a keto diet on when you’re fasting, your body goes really low on carb storage and blood glucose. But your brain needs glucose to function primarily, right? But when you’re low on glucose, what happens then, like your brain can’t stop working, right? So that’s when your body says, Okay, I’m gonna convert fat into ketones. Why can’t fat just go up to the brain and get metabolized for energy because fats can’t bypass the blood brain barrier. So it needs to be converted into a smaller size molecule, because fat has, you know, 18 to 20 carbons sort of long chain molecule so it can’t get past because of the size of a molecule. So it needs to be converted to ketones.

Dr. Mindy  

So it needs like a surrogate

Latt Mansor  

like a surrogate, smaller sized molecule to get into your brain to be metabolized for energy. But then over the years, we have seen research that showed that when ketones are present, the brain would preferentially take up ketones for energy. And in fact, I interviewed Dr. Tommy wood is, you know, brain health experts from from Seattle. He said when you know, people go through brain injury or an infant trying to develop their brain. They are actually use ketone preferentially. So this is super interesting because they’re using ketones to resynthesize fatty acids that is used to repair the structural damage caused by the brain injury. Okay,

Dr. Mindy  

okay, hold that thought for it because you just gave me a whole nother elevator. Okay. So if we are not putting ourselves in, I’m just gonna say a fasted state because that’s the door and I’ve always looked at ketones. I think it’s the best door you take for ketones. If we’re not for eating fat, but we’re not putting ourselves in a fasted state, in order to signal to the body what to do with ketones, then is that fat more stored as fat? Do you see where I’m going with this? Like, there’s, there’s an environment inside the body that needs to happen in order for that to signal Hey, we need ketones. Let’s make ketones. I like to use ketones. And if I’m like, go on the ketogenic diet, and I bring carbohydrates down, I’m like, Oh, they told me to eat a bunch of fat. I eat a bunch of fat. But I haven’t created the right environment in my body, will that fat not turn into a ketone? Will it more likely turn into a fat molecule around my waist?

Latt Mansor  

That I would say no, it would it unless you are having such an excessive amount of calories, that it forces your body to go into storage mode versus burning mode. Because if you are having a maintenance amount of calories, for example, just the right amount of calorie for you to just function and maintain your weight, then inevitably, you will be turning that fat into ketones, because either way your brain will need that energy. And where is it going to get the energy from not glucose because you don’t have any, right. So it’s going to to really pull from the fat conversion into ketones. Okay. And then another interesting fact is that liver converts ketones into BHB, which is the sorry, liver converts fat into ketones, which is BHB, beta hydroxybutyrate, the main form of ketone that our body uses the three forms beta hydroxybutyrate, acetoacetate, and acetone. But the main form that is getting circulated around and get metabolized for energy is beta hydroxybutyrate. And that’s also why whenever you talk about blood ketone levels, when we test it is usually BHB level. The interesting fact is that even though the liver is a conversion organ, that converts converts fat into ketones, it does not metabolize ketone as well, it does not have that sort of as much enzymes does it that liver doesn’t metabolize the heart, the brain muscles. We have seen in heart failure, studies show that the heart the failing heart actually prefers ketones, probably because it’s more efficient, being used as a fuel per molecule of oxygen use.

Dr. Mindy  

So there are different parts of our body that prefer ketone correct over glucose, yes. Is it like the brain is 5050, right? Like

Latt Mansor  

the brain, the brain primarily uses glucose when you have glucose present, okay. But then when ketones are present, even when glucose is present, it takes up the ketone real independent of glucose uptake. So it doesn’t even affect the other substrates uptake. Right. So which means you know, that the brain really wants it, and you just basically providing extra energy for the brain to work.

Dr. Mindy  

So So I always go back to our primal ancestors, and how do they do this. And that actually makes perfect sense that the cardiovascular system would require it because the longer you go without food, the more focused you have to become defined. So that’s why the brain gobbles them up. But you’re also probably running and chasing and going after hunting food, which is why it will go to the cardiovascular system.

Latt Mansor  

Yep. So you have two points there. One is the cognitive benefit, and the other is the energy benefit when it comes to performance. And we can talk about that with regards to exogenous ketones, but most importantly, one study by Mujica Parodi. Two years ago, they published a paper that showed keto diet and exogenous ketones, and then placebo, three groups, right keto diet for a week, exogenous ketones, one dose, and then placebo. And then they measured functional MRI, they looked at the interaction of the brain regions, and they call it brain network stability. And this stability decreases as we age, and that’s when you increase the risk of developing neurodegenerative diseases. Okay. So what they have seen is that both keto diet for a week and one dose of exogenous ketones, they both increase the brain network stability.

Dr. Mindy  

That’s crazy, isn’t it? There’s a part of the brain that didn’t activate

Latt Mansor  

they just showed the increased interaction between the brain regions so the activity the brain activity increase, okay. So, to your point, you know, you are increasing your cognitive abilities, your cognitive sort of focus but also because it goes into your Krebs cycle and produce energy, ATP, especially when you need the cardiovascular fitness, cardiovascular performance. You have it.

Dr. Mindy  

Okay, so now, now I’m gonna go down this path. Yeah, this is like, Oh my God, this would be like what I do on a Friday night is having a conversation like this. It’s very exciting. I know. So is it the mitochondria? If we look at, we have the most amount of mitochondria in our brain, our heart, our eyes, and our ovaries actually are in the female body. The eggs that live in our ovaries have the most amount of mitochondria compared to any other cell in our body. So my brain is thinking, Okay, well, if they’re the most dense amount of mitochondria there, they need the most amount of ketones most amount of managing that would make sense from our primal friends, because our primal friends need to stay alive. And the women need to stay alive and reproduce so that we all can be sitting here today. So do we have any information on what ketones would do for the eyes or for the ovaries?

Latt Mansor  

That would be an interesting study. I’ve never, I’ve never seen any studies, specifically looking at that. But now that you mentioned the theory of it, I mean, theoretically, it would work, it would need a lot of mitochondrial, it will need a lot of fuel to fuel those mitochondria. And therefore, the hypothesis would be like, if I’m providing ketones to the body, then I should be able to see the uptake of ketones in the eyes and ovaries at an exponential level. However, I think the feasibility of running those studies, I mean, because the heart they’ve done it, and in animals where they measure the blood going in arterial blood versus venous blood blood going out, and then that’s how they measure the amount of uptake of different substrates. Right? How would you do that? With the eyes? I guess you can.

Dr. Mindy  

Yeah, be like putting dye. My, my ophthalmologist, you know, dilates and puts stuff in my eyes. So maybe you can? Yeah, but I’m even thinking for Well, I’m thinking two things. One is, you know, as I went through my 40s, there’s a moment that your eyesight goes, and you can’t read up close. But the more I had been practicing a fasting lifestyle, the more ketones that I put into my body, I’m just seeing subtle shifts, and one of them has been in my eyesight, like, I’m not needing my reading glasses as much. And so the other day, I was wondering, I was like, What am I doing in my life that is allowing that to happen. So it would be really interesting to see how it how it works with with as far as eyesight goes, but the bigger elephant in the ketone room would be fertility, especially women that do we and especially if we did I mean, I know we’re going to talk about like Alzheimer’s and dementia. But do we have any way to measure if putting somebody in a ketogenic state or using exogenous ketones over a certain period of time helped with fertility?

Latt Mansor  

That’s, that’s super interesting. I don’t know, per se. And I don’t know, because I know for a fact that for keto diet sort of ketogenic diet studies, female bodies react differently, slightly different compared to, to male bodies. And I think there was a paper that published the effect of keto diet on basal metabolic rate, basically, the postmenopausal women would be similar to males. Yeah. But the pre menopausal women behaves completely differently, right.

Dr. Mindy  

I just had another thought. Sorry. I have to get this out before because you literally I’ve studied this stuff. And now this is why I love talking to you, like my whole brain is going to new. Okay. So when we look at the woman’s menstrual cycle, when we look at day one, all the way through ovulation, which is the follicular phase, first 15 days, what’s happening is estrogen is coming in, in order to release an egg. And estrogen needs glucose to be low and thrives when ketones are high. And I’m wondering if that’s because that’s what the eggs need that because they have so many mitochondria, and

Latt Mansor  

they’re also actively dividing. And yeah, really? Yeah, where’s the

Dr. Mindy  

back half, you’re like the eggs already released. So it doesn’t need that, which is why all of a sudden progesterone wants glucose to be high. So you actually don’t want ketones in the back half of your cycle. But it may all be based off of the egg.

Latt Mansor  

This is this is how we run a study together.

Dr. Mindy  

I said yes. This is

Latt Mansor  

the conception of our collaboration to run a study. Yeah.

Dr. Mindy  

Because then we could look at something like your, you know, exogenous ketones, and we could say, Okay, how do we use that in an effective way to facilitate a better menstrual cycle and potentially better ovulation for a woman? And I mean, I’ve always thought of as exogenous really helpful, I can see it for Alzheimer’s and dementia. But now you got me really thinking that this is this could be a really powerful tool for fertility. And you also have me thinking, and I don’t know if you all have thought of this is that when we’re looking at an exogenous ketone, it’s probably best done in the front half of the cycle. And then the week before a woman’s period, she would probably not use she would cycle off of the exogenous Right?

Latt Mansor  

Right, right. And that way, you can have that predictable level of ketones in your body, right? Because when you use exogenous ketone is transient enough. And the effects is that the effect is acute enough for you to control when you need it to be on when you need it to be off. Versus when you’re on ketogenic diet, you have that adaptation period, and then even when you cycle off, you will have that adaptation period as well, right. So that gives you the flexibility to really switch on and off whenever you want to be in ketosis.

Dr. Mindy  

So one of the things that I that I did when I developed the fasting cycle in fast like a girl is I tested it on a bunch of my team members that were struggling to get pregnant, okay. And then like, immediately, I was like, let’s try this cycle where we’re gonna go high carb, low carb, and we’re gonna do ketones in and out of ketosis over your menstrual cycle. Let’s see what happens. I have a theory here. Okay. I’m like, I think it’ll take us about 90 days to understand if this worked or not. Within 30 days, both of them got pregnant. And the after, after trying to get pregnant for years, like these women were. So what was

Latt Mansor  

your theory? Then when you when you ran that and you saw that result? What was your theory, then

Dr. Mindy  

the theory was that estrogen wants glucose down and ketones up, okay. And so when a woman is on day seven of her cycle, eating pizza and ice cream, she’s actually making herself more infertile, and she doesn’t really realize it, and then the back half the opposite happens. And so you want glucose up and ketones down? And I hadn’t thought of it in terms of the mitochondria.

Latt Mansor  

Going back into the basic science mechanism, mechanism of action. And that could be why

Dr. Mindy  

Yeah, so so so then I was like, after I saw these two women get pregnant, I was like, Oh, my God, okay, let me try it on my patients. So I tried on my patients, same thing, everybody, like 30 to 60 days, most of them 30. So then I went to my Youtube world. And I’m like, let’s try this. This was the birth of fast like a girl people were writing in. And you know, right now on Amazon, my reviews on the book, I love reading the ones that say, Yep, I got pregnant in 30 days. But what do we do with your product? What do we do with exogenous ketones to facilitate that?

Latt Mansor  

Well, I mean, like, yes, like I said, you know, if you are going high and low, you know, manipulating glucose and ketones intake, you can use this to really boost the ketone levels on a transit level. Because what happens when you drink ketones exogenous ketone, like ketone IQ, for example, is that your blood ketone levels will go up to, you know, one to 2.5 millimolar, over three to four hours, and it will stay above one hour, if you’re sedentary, if you’re not working on Oh, stay above one millimolar after six hours, and then it will start dropping down to baseline. Okay. And then after that, either you have to top up, or you just let it, you know, just flat out on a baseline. That way, you can measure you can even like you can really solidify your theory about the ketones, right and glucose, and you can really pinpoint what exactly what’s the

Dr. Mindy  

number Yeah, but I’m wondering if it’s the health of the mitochondria and the egg. So if you have an eggs that are aren’t viable, you let the root of that you have mitochondria that are this function. Yeah, so and then every woman who’s struggling with infertility is going to have a little bit of a different dysfunction. So where I might need on day 10, to take in one bottle, another woman might need like three. So we, I think that’s where the N of one comes in, where you’re gonna have to figure out what that pattern is.

Latt Mansor  

And that’s when it comes to sort of personalized medicine. And that’s why I love talking to people like you. You have the x the direct contact with people and you touch people’s lives directly. Whereas I’m coming from a basic scientists point of view. And for you guys who don’t know basic sciences means like scientists who always try to investigate the mechanism of action, we look at molecular biology, we look at animal models, and really figure out what is actually happening inside mitochondria, what is actually happening with this particular molecule, whereas clinical scientists are scientists who run clinical trials and look at effects on humans. So when we put one on one together, this world, just you know, we can start explaining the science behind this.

Dr. Mindy  

It’s so funny you say that because this has been my new cry to my to people who are listening is like, science gets us in the ballpark. Now we have to figure out what seat we want to sit at. And it’s we have to take that and we have to apply it to ourself. But I fear that one of the things that we done with science is we’ve held it up as the gold standard. And it’s like, no, it’s it’s just opening our minds. And to your point, we need each other in this conversation as the people listening, we need them as well to give us feedback so that we have some kind of understanding of how humans apply this Yes,

Latt Mansor  

because one is proof of concept. And the other is translate the translation and application into human’s life specifically. And as we know, metabolism is a beast, yeah, when it comes to how to pinpoint and how to really fix, especially when you come up with dysfunctional metabolism. And there is a level of severity, and you don’t know where that level was, and then you need to get into the optimal level, do you overshoot it? And when you overshoot it, it becomes another form of dysfunction? Right? It’s just a very difficult visa tackle.

Dr. Mindy  

I agree. Agreed. So okay, let’s go to the brain. Because now that we’ve geeked out on the ovaries, and you know, the sperm, I don’t know, the mitochondrial makeup of sperm or testes, that would be interesting to know, too. Because this, you know, even though men don’t have a cycle, you know, a monthly cycle, you guys have a daily cycle, right? So

Latt Mansor  

I wouldn’t assume it will have high mitochondria activity, just because they’re constantly being, you know, the DNA materials are being replicated and producing sperms. Yeah, therefore, that activity would sort of be increased compared to the rest of your body, which is just, you know, as demand function, right? Well,

Dr. Mindy  

and the sperm need to be strong. Yeah. strong swimmers. Right. So there’s got to be some mitochondria in there, because that’s the battery of everything of human life. Oh, yeah. 100%. Yeah. Interesting. Okay, so take me up to the brain. When we say that the brain gobbles up my ketones. Do we know what part of the brain is gobbling the most?

Latt Mansor  

That I’m not entirely sure. I do feel I do know that. Ketones does increase BDNF, brain derived neurotrophic factor. And exercise also increased BDNF, right. And BDNF has direct effect on high book hippocampus. Okay, hippocampus is also responsible for learning and memory. Yeah. So we did. And yeah, and I. So I know that that region is very sensitive to ketones being available. Yes. And that makes sense. Because in our $6 million contract with the DOD, we are currently looking at an exogenous ketones in cognitive and physical performance in hypoxia. And in the study, we’re wrapping up now. So we’ve got a lot of data already, that it’s going to going to be published. But we have seen when in hypoxia, and in low oxygen levels, ketones actually increase memory recall, as well as accuracy and reaction time. Because normally, when you’re in low oxygen level, your cognitive function decrease, because your brain is saying, Hey, I’ve got less oxygen, and therefore let’s lower the the activity and therefore that goes with the function. But we’ve seen the increase in in memory recall, as well as, you know, reaction time and all that. And with all these cognitive studies, it just comes to show that hippocampus, you know, when it’s when it comes to like memory, and learning and mood and all that, as well as mood like I recently gave a lecture at University of Malaya as a fellow last month, and I brought kitchen IQ shots and gave it to the students. One of them actually said they they had struggled with anxiety for a long time, but ever since he took the shot 10 minutes after they took the shot, they stop fiddling with their limbs and they said it actually works.

Dr. Mindy  

Well. That’s because ketones I don’t know if you know that when ketones go up GABA goes up. Yes. Yes. So it’s on the GABA pathway. Yeah, isn’t it? Yeah, cuz I’ve told people that all the time like just sit there when you if when you’re in a fasted state, just tell yourself ketones are coming ketones are coming. Yeah. And once they come you’ll go from this. Yeah, to high strangely feel, comrade.

Latt Mansor  

This is the area I love to explain. I would love to hear your take on this. So ketones gets you into that relaxed state and calm state, right. But ketones also give you energy. Yeah. How do you explain that? I’ll give you my take on that.

Dr. Mindy  

I’ll explain it by you have to ketones were meant for your survival. You had to go hunt. And so you can’t be all frazzled. Like oh my god, I’m running out of food. I’m hungry. Ketones are like boom. They’re like they put you in your body. They give you focus so you can go and hunt so you can eat so you can stay alive. That’s how they were developed in our body. And so that they had to bring GABA up. They had to bring dopamine up Because dopamine is that motivation molecule is like, let’s go get that food. That’s all to me. That’s what we’re all searching for. And once we click in that ketone, we’re actually in a hunter state.

Latt Mansor  

So you have to be calm, collected, focus, laser focus, and at the same time, being able to really sprint out and use that physical prowess that you have in order to get that food. And the way I explain it is, especially when it comes to exogenous ketones, is that you need to stop thinking about it like a stimulant. It’s not a caffeine, it’s not a stimulant. So it’s not actually giving you the extra boost by blocking adenosine receptor and make you feel less fatigue, but still not give you energy, that stimulant, right, it increases heart rate increases blood pressure, but it doesn’t directly give you energy, you still need to pull the energy from somewhere. Yeah, ketones directly gives you energy, but also gives you the signaling effect of the calming and zeolitic effect via signaling. And therefore you don’t need to be in that jittery, like frazzled sort of moment. Yeah, like you said, and that’s why you can use in both physically demanding situation. Yeah, but also in a way to calm yourself down, especially if you have anxiety. And I think a lot of people now starting to realize one good use of exogenous ketones is when they want to go for exams. Yeah, interviews, podcast, because they’re calm. Yeah, but their brain is switched on. So they can actually, you know, think better and really have the memory recall dialed in. Yeah, but at the same time, they’re not having this nervous energy. That is stopping them from thinking clearly,

Dr. Mindy  

that the first time I learned about fasting and a ketone, I was experimenting it on myself. And I was trying, I used to give these big presentations to my patient base. And we would do a big one to hundreds of people every January to kind of set the the year off. And so I wanted to bring fasting to them. We had just learned about Dr. O zoomies work Valter Longo come out with his three day water fast.

Latt Mansor  

So that’s a very interesting point we’re gonna get into.

Dr. Mindy  

So I was like, they’re gonna think I’m crazy, because I’ve been talking about nutrition and detox. And now I’m going to tell them that actually, all the supplements, all the food, things I’ve told you pale in comparison to what I’m about to tell you. So I went on a five day water fast. And on the fifth day, I gave the presentation. So I hadn’t eaten in five days. And I did it on purpose, so that I could show the my audit my patient base, this is what it looks like to be on ketones. And so I give the whole lecture, it was a two hour lecture, and about 90 minutes. And I just said, and I know you probably think I’m crazy. And I want you to know, like, do I look tired right now? And they’re all like looking at me kind of funny. You show your foster for five days? Yeah. And then I just Well, I did. And I just said to them, I was like, I haven’t eaten in five days. Yeah. And everybody was was convinced at that point. And it was because I had ketones in me to sort of give a speech to stay calm. I wasn’t hungry. It, it was a performance moment. Yeah. And I think we lose sight of that. Because everybody comes to ketones thinking, oh, I want to lose weight. But I always say Come come in to lose weight. And then I’m going to ask you to stay for all the other benefits, right?

Latt Mansor  

Exactly the way I describe what is the use, I remember when we launched it early last year, we had a whole list of use cases and benefits of ketones, right? You get the cognitive benefit, you get the performance, you get the recovery, and then you get the metabolic health. But then, after all of that, it sounds like snake oil. It sounds too good to be true. So right now, it’s my favorite way of describing what’s the best use case and what’s the best benefit of ketone is that it will benefit you in any activity that you use your brain for. Yeah. So either you’re using it for intellectual, cognitive performance side of things. Or if you’re using physical side of things, because even when you’re doing physically demanding tasks, you still need your brain, people on long rides on on long runs, they still need that focus people on trail runs, they need their sort of alertness and focus of their surrounding their balance and everything. People who are doing an aerobic exercise, they still need to be in the zone to get the form, right to think of all everything, you know, the weights and all of that. So you’re in your primal state, you’re in your primal state.

Dr. Mindy  

So okay, now I’m going to really geek out on a part of the brain. Yeah, I have been currently this week writing a whole chapter for my new book on all right, and you’re on the

Latt Mansor  

road. You are always on on it, you’re always on it.

Dr. Mindy  

Well, I love to solve problems that that our culture isn’t solving. And one of the biggest problems that we see right now with with women going through menopause is that there’s this massive brain change. And one of the pieces of The brain has a receptor site known as 5-HT2A, which is a serotonin receptor site. And estradiol goes into that and activates serotonin, which helps with keeping us joyful. When estradiol goes away, we have this empty receptor site. So I’ve been looking at what else do we have that can go into this receptor site? Well, one study that I came across was that something as little as eight hours of fasting will activate the serotonin 5-HT2A receptor site. And now, in the end, regardless of what diet they’re regardless of what diet eight hours seems so minimal, sleep overnight. Yeah. And it’s in the hippocampus that that because we have five to h2 A receptors all over our brain, but it’s in the hippocampus that it activates, which is why they actually think fasting isn’t it can act as an antidepressant. But I’m thinking it’s because the ketone goes into that receptor site. So do you know any studies on that receptor site and keto?

Latt Mansor  

I haven’t I haven’t seen any anything specific to that receptor site. And I’m I’m, and I know in terms of receptors, things are very specific, right? It’s very unlikely that a foreign molecule will bind to that receptor site. But then again, a lot of studies also shown that ketones have direct effect on DNA as a signaling molecule. They call it beta hydroxybutyrate relation, because we know methylation of DNA and it causes, you know, difference in gene expression. Right? So they found out that beta hydroxybutyrate, which relation is the thing now, it’s it’s a mouthful

Dr. Mindy  

to say bhp, yes.

Latt Mansor  

Yeah. So it does have effect by binding on sites that we didn’t know that they bind. So I think the area is still very new. And I spoke to my, my supervisor back in my PhD days and Oxford couple of months ago, and she’s still in the research area. And she’s like, the next big thing now is metabolites as signaling molecules, because we need to stop looking at all these metabolites, just as energy fuels. We are looking at it as signaling molecules, like how glucose does not only provide you with energy, but it’s going down this cascade of pathway that’s, you know, working in tandem with insulin glucagon GLP. In in a different sort of setting and cause a whole different phenomenon of inside your body.

Dr. Mindy  

Okay, so yeah, I get it forever. So this leads me to the next question, which is, is there an environment in which an exogenous ketone is welcome in our body? And is there an environment when it’s not welcome? Like when I first heard about taking an exogenous ketone, honestly, my first thought was, well, that’s cheating. And I’m like a hard work.

Latt Mansor  

So many people say that so many people, why would I take exogenous ketones when I’m burning my own fat and turning it into ketones? And that’s an easy question, right? If, let’s say if you are going on a ketogenic diet, to lose weight, right, the goal is for you to access your fat storage and turn it into ketones and also burn the fat directly as an energy. Feel. Sorry, as an energy source. What are you eating mainly? Fat, right? Your own fat, your own fat, their calories, right? Yeah, I guess they are exogenous ketones. They are a source of calories, right? If you’re on a ketogenic diet to get into ketosis, you’re going to get the source of calories anyway. Why not have a portion of that be a direct form of keto?

Dr. Mindy  

Okay, so but what if my blood sugar if I just ate a meal, my blood sugar went up. So now I’ve got all this glucose for the body to use. And then I tossed down some exogenous ketones.

Latt Mansor  

That’s another use case. So studies, a few papers have been published by Dr. Jonathan Littell, from University of British Columbia, Canada. When you take exogenous ketones across the board, they have seen lowering of blood glucose, oh, my God, this is acute and you can you you know, you can take my word for it, because we’ve measured it ourselves. We’ve had people with a Keto con when I met you, yeah, we’ve got people with continuous glucose coming up to us. We gave them a shot, we’re like, come back in an hour. And let’s measure your glucose. And if it dropped 40 to 50 points.

Dr. Mindy  

It’s like apple cider vinegar. It’s like apple cider. Everybody, by the way, just so you know, I do. I do all these science dense videos on YouTube, and they do well. And then I throw out apple cider vinegar, and everybody goes crazy. Yeah, I had

Latt Mansor  

my CGM a couple of days ago, and I drink ketones before I go to bed. And then they’d start asking the app asked me it’s like, what did you your your your glucose was 70 when you go to bed, because I drank ketones, but at the same time you don’t feel the hypoglycemic effect. No, I never thought so one hypothesis that the scientists that don’t Dr. Jonathan little sort of hypothesize is that when you take exogenous ketone, you are sending signals to the liver to lower gluconeogenesis. gluconeogenesis is a process of making sugar from other sources, like glutamate from, you know, fats and proteins and all that. That is especially true when you are on a ketogenic diet or when you’re fasting. Because either way, even when you’re on low glucose, you measure your blood glucose, you still have a baseline, you still have four or five millimolar. Right? Where does that glucose come from? You’re not eating right, sugar. So it’s from gluconeogenesis. I was just gonna say it. Yeah. So gluconeogenesis also happens at all times, even when you’re eating sugar. Okay, so your body balances it, right? It balances it by saying, Okay, this is all the external sugar, I’m going to use it, but at the same time, it’s a flux is a balance of you producing your own sugar. Same with fat, when you take in fat, it does not just go into your muscles and get used to right, it gets repackaged, it gets redistributed into the body and turn it round. Right, right. So this is what they hypothesize, when you have exogenous ketones, you’re lowering that glucose production in your liver, and therefore it reduces the overall blood glucose level. But that also shows that your body perceive ketones as a energy source that you have plenty that you don’t need to produce the glucose anymore, right. So that’s, that’s the main point here, exogenous ketone and endogenous ketones. While it is a little bit different in nature, because you’re not producing yourself, ultimately, the molecule is the same. So the your body will still recognize it as ketones. BHB is BHPs. BHP is not a novel magic molecule that the pharmaceutical company whips up from a genetic modified organisms, it is literally the same exact molecule that your body will produce.

Dr. Mindy  

So a big challenge that a lot I see with a lot of fasters is that when they eat dinner, their glucose goes up. And then they go to bed and somewhere around two to three in the morning, all of a sudden, the blood sugar dipped so much that it causes this. I mean, it’s the dawn of fact, right, the liver secretes a bunch of glucose into the system in order to be able to you know, regulate itself. They wake up at two or three in the morning, they get the next you know it when they actually wake up and get out of bed in the morning, they look at their glucose, and they’re like, oh my god, it’s higher than it was before I went to bed. So if that theory you’re talking about is right, could we use exogenous ketones before we go to bed to stop that two to three wake up that the liver does because now the liver has a sensor that tells it you don’t need to I can

Latt Mansor  

literally show you my glucose data right now. Like when I’m like asleep, like it literally flat flattens out.

Dr. Mindy  

That’s so Oh, so you don’t even when you’re sleeping? It doesn’t even have like spikes up and down. Typically see? Have you tested it on? Like your aura ring?

Latt Mansor  

Um, I? I have? Yes, um, it hasn’t shown an improvement. I mean, we tried doing it in a study as well to look at HRV. And although sleep quality wise, we are still a bit far from from being able to test how effective it is. But in terms of blood glucose levels, yes. Yes. So we know that it flattens out when you sleep.

Dr. Mindy  

And so there’s two new places that I’ve never ever thought to use ketones that you’ve really expanded Well, I think we have more than two. But right now in this moment I have which is before bed for sleep, which I just want to tell you for menopausal women, that would be a game changer because as we lose progesterone, we also don’t go into as deep of asleep. And then after a meal after meal, yeah, bring down glucose, so that my brain goes to because

Latt Mansor  

and then the interesting thing is another way you can check is when you work out. Like halfway into the workout into the end of the workout, you’ll see your glucose go up a little bit because your body starts sending signals to say that, hey, you are doing something physically demanding, therefore creates more glucose, right? But when you have ketones as a pre workout, you don’t see that spike. Oh, but you have energy.

Dr. Mindy  

Okay, so but as a pre workout, if I’ve got ketones in there, I’m not going to get as much release of sugar out of the muscles and maybe I want to like show more definition. So I kind of want the release of muscle of a have glucose so that it like breaks down fat. Do we have any research on like what it does as far as muscle maintaining muscle as far as you know, leaning muscle out.

Latt Mansor  

So there is a study that looked at another form of exogenous ketone, acetoacetate diaster, they looked at Caixa, so muscle loss due to cancer. And these showing that ketones actually help retain muscle. And we know that from a recovery point of view, there is a study that looked at having ketones together with protein, and carbs after workout. And they looked at it from an in vitro point of view, looking at biopsies of muscles, they actually up regulate the leucine mediated mTOR activation. And that is essential for protein synthesis, which is also essential for recovery.

Dr. Mindy  

Wow. So if I’m going on a three day water fast, and I don’t want to lose a lot of muscle, then take take exogenous ketones is preserving that correct?

Latt Mansor  

And a lot of people ask the question, will I bring my fast because it contains 70 calories. And Cynthia Thurlow. And myself, we talked about this on our podcast is that when you are fasting when you go in on waterfalls, what kickstart the ketone ketogenesis, right, the ketone production, it’s when you’re low on sugar. When you’re low on insulin, right, you’re starving yourself, and therefore your body kick starts the ketogenesis. When you have 70 calories of ketones, it doesn’t increase your glucose level, it doesn’t increase your insulin level, there is no reason to believe that you won’t kickstart your keto Genesis. But also, this brings back to the conversation of Malta long, too long go study, fast mimicking diet, they are giving these participants 500 to 750 calories worth of food, and they can still mimic the effect of water fast. So 70 calories is nothing,

Dr. Mindy  

you’d have to have 10 of those in a day

Latt Mansor  

10 of those. And also acutely, what they have seen in animal models is that when you take exogenous ketones, you are up regulating all the transporters enzymes, which are relevant to ketone metabolism, which means when this is transient, after six hours, it goes back down to baseline, you are now tapping back into your own endogenous ketones, you have upregulation of all these different enzymes that’s needed for ketone metabolism. So you are primed and ready to burn more ketones from your own body.

Dr. Mindy  

Oh my God now Yeah, me thinking like, Well, why would you fast without exogenous ketones? What like you like it’s next level?

Latt Mansor  

It’s next level.

Dr. Mindy  

Okay, so then where would we? Where would we use this? For like Alzheimer’s, dementia, I hope everybody listening knows how I’m going at this from menopause and women now. And I hope people take this seriously and try it with like fertility and things like that. But let’s talk about

Latt Mansor  

love to find out more about that. But yeah, that’s not my area of expertise. And I know a lot of our audience are also women who are interested in metabolic health, especially, you know, as we’re aging, we know that all these different risks, and all these different foods that we’re eating that putting us at risk, right, so I would love to hear more, you know, after you experiment with it, and really like real life, examples, real life cases of what’s going to move the needle to do

Dr. Mindy 

Yeah, well, we’ll put the links to your products in there. So people listening, please, go go try this and see, because fertility is expensive. Yep. And it’s, it’s, you know, breaks people’s hearts. And, and yet the body was meant to reproduce. So if there’s an issue where the body is not able to reproduce, then we got to fix that. And it’s coming back to a molecule that’s as innate in our body as our blood is, is a ketone. And yet the world half the world is not even getting the ketones disclaimer,

Latt Mansor  

though. It does not taste like soda does not taste, right. We’re working on the flavor, but knew this. The reason why we are surviving and thriving is because when people take it, they feel the subjective preference. And regardless of the taste that people are taking it for the benefit. Yeah. And what’s very, very funny is that most people that have been taking it long term now they’re like, actually don’t mind the taste,

Dr. Mindy  

and you get used to it. Yeah, that I can totally see that. Yeah, you know what I always say, when you like, take a shot at something that’s healthy, and you’re like, Oh, I hate that. I’m never gonna do that. I always think Well, what did you do in college when you’re at a bar and like they gave you like, you didn’t just you didn’t go oh, I don’t like that. You’re like, give it to me. I feel I want the effect of it. So

Latt Mansor  

that’s a great example. That’s a great What did you think when you would write what were you thinking?

Dr. Mindy  

What would you tell your 21 year old?

Latt Mansor  

So now Now we’re talking about therapeutic users. Yeah. Because I think, you know, like, like what we’re seeing everything that uses your brain, every activity that uses your brain. You can benefit from having ketones in your body. I don’t care whether you get occasional ketogenic diet or fasting or exogenous ketones. As long as you have the molecule in your body. Yeah, you will. Granted, you need to get at least above one millimolar. Right in your blood for you, but like, Okay,

Dr. Mindy  

wait, why? Because the the measurement people in my community get 0.5 0.5. Yeah, but everybody’s like, well, more is better.

Latt Mansor  

Okay, great, great conversation. Okay, so the definition of ketosis is anything above 0.5. Right. But for therapeutic users, a lot of studies shown around one millimolar, anything above one, you start to see effect already. Okay, for performance, we’re looking at above two millimolar. Oh, wow. Okay, I’d love to millimolar but also not meant to subsidize or replace glucose. It’s meant to be used together so that you you have the hybrid fuel system. And yeah, I know, you want to talk about this about high sugar, high, high ketone levels, we can go into that later. But most importantly, when we talk about the threshold, we want to make sure that it’s in the optimal level, like I said before, right. Metabolism is in the Goldilocks zone. Yes. And the reason why I tell you, more is not better is that we have seen this in study and this I can say confidently, in the military study, we dosed them via weight match dose, so we do 0.5 grams per kilogram of body weight, which means some of these guys are big, they’re like 8090 kilograms B, right. So you are getting ketone esters that study we use the kitchen esters, that getting about 4050 grams of ketone esters, and one disadvantage of ketone ester. The advantage of ketone ester is that it can spike your blood ketone levels between three to five millimolar. Quite high quite quickly. ketone IQ is not ketone Ester ketone ester is a BHB molecule bound with butane dial and then as the form so that’s why it’s called ketone ester. What we have found is that because it spikes it too high, it also increased blood acidity, it lowers blood pH, because BHB is beta hydroxybutyrate acid, and it does cause your blood to be acidic by the body. So over time, when you spike it too quickly, in a short amount of time, you increase your cardio respiratory stress, biomarkers, your heart rate, your breathing rate, because you’re trying to expel the carbon dioxide to neutralize it. But most importantly, because half of it is butane dial and half of it is PHP, the PHP goes straight into your blood, which means it’s dose dependent. So the more you drink, the higher BHB will go. So initially, we thought the more the better, right? The higher the better. No, so some of these people were having blood BHB of 678 millimolar. And they start to not feel well. They just feel unwell in general, just wanting to puke and just your body trying to expel it because it’s just too much. It’s the same Yeah, it’s the same when you overdose on glucose, right? You don’t even have to hydrogen just don’t feel well, it just generally you feel unwell. And I think this is the case with ketones as well, even though it’s good for you, even though it’s an energy source, but if you’re not using it, it’s just sitting around, your body will try its best to balance it out and in homeostasis and into this, this optimal zone.

Dr. Mindy  

So what this actually leads me to a unique question that I’ve seen with just a handful of people, which they feel worse in ketosis than not in ketosis, and my brain was always like, okay, the ketones are going, they’re going to repair something. So what needs to be repaired in the body? Yeah, but what based off of what you just said, even if somebody’s at like, point 7.8? Is it possible that that could be too many ketones? Um,

Latt Mansor  

from what I’ve seen on the overdosing is usually five and above. Right? So if they’re on round 3.8, point seven and not feeling well, chances are, I think they are just doing it too quickly, the adaptation period, they’re not used to it, therefore, they’re going through the Keto flu. So it could be something to do with electrolytes, something to do with dehydration, because when they lose glycogen when they first go on keto diet, they shed all the glycogen off with glycogen. It’s also comes with water storage, right? So it could be that

Dr. Mindy  

do you find that do you ever see the Keto flu with exogenous ketones? Because I don’t hear about the Keto flu very much anymore, but I like I said, I am seeing some unique cases where they go into ketosis and they, you know, my my theory is you go in, you go out, you go in you go out and so in these cases, we’re doing that for a very long period of time, but they’re still not feeling well in the ketogenic state. So but that would fall into the category category of a Keto flu. So if I gave that person if I said that person

Latt Mansor  

fed them breakfast, that’s one. Yeah, go ahead, yeah, fed them

Dr. Mindy  

breakfast, and then gave them exogenous ketones so that they get the benefit? Would there be a different response? That’s

Latt Mansor  

the perfect way to find out whether if this person is feeling unwell because they are if it’s too high ketone levels, or if it’s keto flu, because with exogenous ketones is predictable, you know, you will get their ketone levels above one, or close to one. If they’re still feeling unwell, then it could be the ketones, but if they’re feeling good, then the ketone is doing the work, but they’re not going through any electoral like, problems

Dr. Mindy  

changes. Okay. This leads me to my next question, which is, could you and you know, I’m not advocating for not fasting, because I think there’s so many therapies. But But let’s say that everybody decided, I don’t want to fast anymore, and they just wanted to eat again. And we gave everybody a bunch of exogenous ketones, are we getting the same benefit? When we take an exogenous ketone as compared to the in endogenous ketone? Are they are they the same benefit?

Latt Mansor  

That’s a great question, Mindy. And this is a question that I’ve been asked a lot, because a lot of people are like, Oh, that’s cheating. You know, I’m not achieving what I’m trying to achieve with keto diet. So when you look at the molecule, like I said, it’s going to be the same molecule. And therefore, if you’re looking at any signaling effect, or any energetics point of view is still going to be the same, you’re still getting the energy from ketones, you’re still getting the preferential treatment in different organs with ketones, and you’re still getting all the signaling benefits from ketones. How ever whenever you’re doing keto diet for a specific reason. You may not be able to achieve that with exogenous ketones. And I’ll tell you certain situations here. If you are specifically aiming for lower glucose level and lowered insulin level, yeah, you can’t get that with exotics. It’s even though ketone, exogenous ketones can acutely decrease blood glucose level, it does not have any effect on insulin, right. So if you’re still on a normal diet, you are still going to be regulating the blood glucose, the glucose you getting from the carb intake, as well as your insulin.

Dr. Mindy  

The body by the way, that’s because the body is so smart. Yeah, that the body’s like, I don’t need to make insulin, right, because this came from the outside,

Latt Mansor  

right, and they get lepsy treatments with keto diet, I don’t think exogenous ketones would be as efficient because you need to be that’s another thing in terms of prolonged period in ketosis, because when you’re on exogenous ketones, you need to top up regularly to be in the ketotic state in a more consistent way. Whereas ketogenic diet, you don’t need to think about it, don’t worry about it. If you want to get into a deeper ketosis, you want to reach a higher blood ketone level, then exogenous ketone could help augment that, right? But it may not help you achieve whatever you’re trying to achieve by getting on a keto diet or fasting. Because if you say fasting to lose weight, right, you are mean you are, you’re emphasizing on lowered calorie intake, lowered insulin and all that. It’s very unique to fasting. So I want people to think about ketones, not just as a magic molecule. Think about it as a tool that’s helping you to achieve what you want to achieve if you’re fasting to lose weight. But because ketones exogenous ketones have appetite suppression effect, and it gives you the focus, right to augment your fast, go do it. Right, right? Don’t not fast just because you can get the benefit. Briefly just

Dr. Mindy  

sit on your couch and eat a bunch of pizza and ice cream and drink ketones.

Latt Mansor  

It’s not a magic molecule, right? You still need to do that foundational work if you know you want to lose weight, you still need to go exercise and all of that.

Dr. Mindy  

The way I look at it is that when the body makes endogenous ketones, it’s making it because it’s burning fat. So if you’re trying to lose weight to your point, you just drinking a bottle of ketone IQ is not going to be like oh my god, now I’m all of a sudden

Latt Mansor  

losing weight. And it is it has calories.

Dr. Mindy  

It has calories. But what it is doing is it’s killing hunger. Yes. And what it is doing, we just discovered it or I just discovered is it’s lowering blood sugar. So it is a part like you said have a tool to be able to put you on your weight loss journey. It is not the thing that it’s not like the thing that’s going to make you lose weight

Latt Mansor  

and just a sneak peek. Currently, I’m talking to a researcher from UBC as well who looked at the blood sugar lowering effect. I’m talking to another researcher within the same university, we’re looking at running a study specifically on appetite suppression on hunger hormones on ghrelin. And there was a study that showed that butane dials specifically which is the raw ingredient and ketone IQ, increased leptin sensitizing effect in the brain, which means you feel more satiety, you can have higher satiety compared to placebo, and we’re looking at calorie intake as well. So when that study, you know, publish, it’s going to be huge, because then now people can confidently say, Hey, I’m taking exogenous ketones, not as a replacement of my lifestyle of my Keto diet, or of my fasting lifestyle, but I’m using it as a tool to really augment it make my fast easier, because I don’t have to think about food all the time, I get the focus I need I get productive throughout the day. And same thing when I’m on ketogenic diet, I feel like you know, I’m not getting in deep enough ketosis, so I’m augmenting with exogenous ketones, or I am going through this, this really difficult adaptation period. I’m ticking ketone IQ so that I can upregulate the enzymes needed to prime my body to be able to metabolize ketones better.

Dr. Mindy  

Well, I’ll tell you, like, I’ll use myself as an example. Yesterday, I had a really long day, and I didn’t get enough food in me, I woke up, I was a little hungry. I was like, Okay, what are you gonna do? You know, I’ve interviewed here with you, I’ve got one in a couple of hours. I’m like, What am I going to do? Am I going to eat Am I cannot eat. And then we, we took a shot of keto ketone IQ. I’m not hungry anymore.

Latt Mansor  

So think about it. Now after this, Kelsey and I were gonna go work out and film some content. And I’m definitely gonna take another shot. But I’m not hungry. I’m not thinking about food. Yeah,

Dr. Mindy  

it’s really cool, because it does turn off that hunger hormone. So it’s quite impressive. The interesting

Latt Mansor  

thing as well, sorry to cut you off now is that while it turns off the hunger, sensation, and it keeps keeps you satiated. In a study that looked at recovery, when people are exercising, they increase the calorie intake. They the participants, the cyclists will given food at libitum. So they can eat whatever they want, however much they want, but because they’re exercising, they’re actually increasing their calorie intake, but also corresponding to that they increase their performance by 15%. In terms of work output after three weeks, using after using ketones, carbon and protein as recovery. Wow. So the way I like to describe ketone is an adaptive fuel. Yeah, it up regulates and down regulates and things in your body, depending on what you’re doing.

Dr. Mindy  

Would you take it every day? Are you just I take it every day? Yeah. And do you? Would you do it intentionally? Like, I’m gonna go workout? Correct? Hey, I’m gonna be on a podcast. So it’s a performance enhance some

Latt Mansor  

some people take it on a just in the morning, just just as a ritual kind of thing. I prefer to take it on a very intentional, like, I’m going on a podcast, I’m going to take this, I am going to bed. I’m going to take this I’m going to go work out. I’m going to take this Yeah. So that for me has worked. But I also know a lot of people on our team themselves, they just take it one shot in the morning just to keep themselves productive. Yeah. And that’s why it’s very interesting, because you can use it as pre workout. And before bed. Yeah.

Dr. Mindy  

So Okay, I gotta summarize this. We’ve talked about it potentially helping with, with infertility because of the denseness of the mitochondria and the eggs. So everybody go try that. We’ve talked about it for depression, because of its what it does in the hippocampus. We’ve talked about it for lowering blood sugar, post meal, so we can put weight loss, you know, gosh, weight loss is all over this conversation, whether people realize it or not. We’ve talked about it taking down hunger. We’ve talked about it helping with sleep, so you don’t create gluconeogenesis at two in the morning. Performance when you are when you’re actually going to work out up regulating these ketones. Anything I’m missing brain health, brain health.

Latt Mansor  

We talked about Alzheimer’s, brain injury, how BDNF and how ketones are actually taken up by the brain to create the fatty acids needed for structural structural repair. Right off the brain. Yeah, and then and then that’s very important for Alzheimer’s dementia, or these neurodegenerative diseases. Those are the areas we

Dr. Mindy  

talked about cardiovascular Cisco DeVos I was new you cheat. You taught me that today. Yeah. So and what I love and I hope people are gathering this and and this is my jam just in life is bringing to people that are passionate about similar things together and going hey, how does your work and my work come together so that humanity can win? Yeah, let’s change the world. Yes, exactly. So Okay, I have to finish on this comment. These are these questions. This is my theme for the for the year is self love. So we’re going to take it away from ketones, although I do know that ketones are a form of self love.

Latt Mansor  

So the challenge is for me to take it back into ketones. Yeah, right.

Dr. Mindy  

You can answer this without the letter K, yeah, coming out of your mouth.

Latt Mansor  

Your audience should have a drinking game. Every time we say keto, they’d have a shot. Sure, there’ll be floored by the end of this.

Dr. Mindy  

Or they’re gonna be like so like, buzzing that they’re not gonna sit there that didn’t stick with the podcast and probably went out what worked out? Yeah. Well, do you have a self love practice? And the second part of that question is what do you think your superpower is that you bring to the world?

Latt Mansor  

Oh, boy, I Okay, let’s let’s go to the first part first. I think self love. I always thought I have self love. Right. And I grew up. Like I said, my family site has high prevalence of chronic diseases. So my mom’s side has has really high prevalence of obesity. And I grew up overweight on my life. And this is a story that I share a lot with Ben Azadi because he has gone yeah, he’s got a huge weight loss journey. Yeah. So I used to hate how I look. And I worked out and worked out and improve how I looked because I hated what I was, or how I looked before. But now, it’s just a simple switch of perspective. I work out and I want to be healthy, because I love myself. Because I was given this body this metabolism, this family this genetic, and there’s only one of me. So why not love myself enough? To make a change? Yeah, why not love myself enough to do something good for my own body. And I think that’s from a physical point of view. Yeah. And mentally, I always thought, I love myself as well. But then I realized I didn’t until two years ago, because growing up in Asia, your self worth is most often than not tied to materialistic stuff. Your parents would love you more. If you go to a better university, if you get straight A’s. If you become a doctor and engineer, a lawyer, that’s pretty good paying job. And I’m sure a lot of people grew up in Asia, even here in America, you know, some families, they can relate to this, right? The tiger mom, right. And I know my mom wants the best for me, and my parents wants the best for me. But at the same time, that became my foundation, right? So I tie my self worth to all of these things. But then I never love me for being me. So I started meditation two years ago now. Although I could be more consistent with it nowadays. And it really took me out of that inside view to a third person point of view, if you wouldn’t, I’m able to zoom out. And look at that and realize that and just realizing that. I think the first time I meditated, I cried. Because it was it was a guided meditation, it says put your hand on your heart. Love yourself and be compassionate with yourself. And then that was when I realized I never did. I loved people, my accomplishments. I loved where I got in life. I loved what I am in terms of I’m a scientist. I’m an educator, I’m a science communicator. I’ve never loved a lot, man. So I forgot about it. And that was when I realized, and that’s when everything else does not matter. Not money, not failure. It’s what I do what I’m passionate about. And when I leave this world, I asked myself, I always ask myself, if I die tomorrow, will I have any regrets? And this and the goal is always to say no. That you’ve done everything you could and full of love for yourself and for people around you. Yeah. So

Dr. Mindy  

that was like the best answer I’ve been given. There’s been some good answers. Okay.

Latt Mansor  

Does this fit for the inaugural interview?

Dr. Mindy  

Tell me what, now tell me what your superpower is. I think I just found

Latt Mansor  

my superpower. I think my superpower is something that I really cherish is the ability to connect with people. Yeah, because when I was overweight, I was always that friend that can people can count on but not that friend when when people want to have fun with or when you know I’m that that overweight friend or friend was like oh, you know lots good with his homework. Look, let’s talk to him when we need him academically, you know, because he’s smarter, but when it’s like, oh, he’s not the cool friend, you know, he’s not the cool guy. But that helped me develop my personality that helped me to come out of my shell be an extrovert. And that helped me really put an effort into how do I connect with people? How do I remember first? And first and foremost, always remember the person’s name? Yes. Appreciate that. And then you think about what are the common things that you could connect with and that you can talk about? I’m always conscious of that and intentional when it gets to that. And then when you connect, everything else is magic. Yeah, I agree. I think that for the worst for the better. That was not the most, you know, some of the experience, we’re not the sweetest. But the lessons nonetheless, was something that I can take with me for the rest of my life, and I will forever cherish it.

Dr. Mindy  

Yeah. That was the most beautiful, is literally the most beautiful answer that I’ve been given an n is at the heart of why I do what I do. Because we have a culture that looks at skinny, beautiful, and says that’s successful cars, you drive. That’s what we’re all going for. And we lose sight of the, the bumps along the path, and the internal conversations we have with ourselves, and how we start to orchestrate a whole our whole life around those internal conversations. So what I hope everybody gathers from what you just said, is you had some really rough moments, and you change the internal conversation, and that changed your life.

Latt Mansor  

Yeah. And no matter what kind of experience you have bad or good, it’s still part of you. And it’s what makes you you now and what matters is now Yes, not the past, not the future. It’s now what you do now matters most. So focus on you now whatever you can do now just do it for yourself for your people that loves you for for people who are around you. And even for people who do not love you prove them wrong.

Dr. Mindy  

One of my favorite quotes I’m a big quote fan is Don’t Don’t think about what the world needs. Think about what lights you up, because what the world needs is more people that are lit up. And that’s that’s that’s the goal to me. That’s what we’re working towards. So how do people find you lot this was just incredible can

Latt Mansor  

find me at last month so la ti t ma n s o r on all social media platform and also hmm podcast on Spotify, Apple podcasts, all all podcast platforms, as well as YouTube. And yeah, send me messages. I do answer them and comments and happy to share

Dr. Mindy  

Yeah, and test everything we talked about. And then give us both feedbacks. Yes.

Latt Mansor  

Amazing. Appreciate it. Thank you. Incredible.

Dr. Mindy  

Thank you so much for joining me in today’s episode. I love bringing thoughtful discussions about all things health to you. If you enjoyed it, we’d love to know about it. So please leave us a review, share it with your friends and let me know what your biggest takeaway is.